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Fig. 7 | BMC Cancer

Fig. 7

From: Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/−-driven murine colonic adenomas

Fig. 7

Colonic adenomas resulting from inducible loss of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)+/− stem cells have abnormal splicing patterns. The tumors consistently displayed abnormal patterns of intron retention in several RNA-binding genes. The Lrig1-(Apc-Flox) tumor transcriptome is characterized by a loss of intron retention in RNA-binding genes. Abnormal patterns of gene splicing were observed throughout the mRNA pileups of genes involved in RNA-binding, including the genes FUS RNA-binding protein (FUS) (left) and metadherin (Mtdh) (right). RNA sequencing reads from matched adjacent nontumor (‘normal’) tissue (top) and adenoma (bottom) are plotted

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BMC Cancer

ISSN: 1471-2407

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