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Fig. 6 | BMC Cancer

Fig. 6

From: Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/−-driven murine colonic adenomas

Fig. 6

The tumors exhibited substantial transcriptome similarity to each other. Top: Principal components analysis of tumor transcriptome data compared to colons from untreated wild type mice. Tumor and wild type colon transcriptomes form distinct groups based on principal components analysis. Bottom: Heatmap visualization of highly significant differentially-expressed genes in the colonic adenomas. Rows are genes and columns are tumors. Genes colored red were up-regulated (top 15 rows) and genes colored blue were down-regulated (bottom 15 rows). Expression levels were normalized against that in the wild-type colon sample (black column on left). Many genes down-regulated are involved in detoxification of exogenous carcinogens

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