Fig. 1

Colonic adenomas resulting from inducible loss of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)+/− stem cells are hypermutated and genetically heterogeneous. Exome sequencing of adenomas from Lrig1-(Apc-Flox) mice detected the presence of ~25 to 35 high-quality somatic mutations per megabase, with an abundance of C:G>A:T transversion point mutations. The number and type of somatic mutations from each adenoma exome is plotted. There were nine adenomas from three mice; each column plots three tumors from a single mouse. Similar mutational frequencies and motif distributions were observed across the nine tumor exomes sequenced