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Table 4 Univariate and multivariate analysis for the association between clinical characteristics and progression-free survival

From: Early onset neutropenia: a useful predictor of chemosensitivity and favorable prognosis in patients with serous ovarian cancer

VariableUnivariate Multivariate 
 HR(95% CI)P valueHR(95% CI)P value
Age (year)
 <501   
  ≥ 501.352(0.980–1.866)0.066  
FIGO stage
 I-II1 1 
 III-IV2.577(1.717–3.868)<0.0013.337(2.049–5.436)<0.001
Histological grade
 Low1   
 High1.250(0.852–1.835)0.254  
Lymph node invasion
 Negative1 1 
 Positive1.608(1.107–2.336)0.0131.069(0.692–1.653)0.763
Tumor residual (cm)
 Optimal(≤1)1 1 
 Sub-optimal(>1)1.732(1.204–2.466)0.0031.314(0.864–1.997)0.202
CA125 level (U/mL)
  ≤ 351 1 
 >353.156(1.468–6.785)0.0031.454(0.621–3.407)0.388
Severity of CIN
 Mild versus Absence0.241(0.139–0.419)<0.0010.593(0.322–1.092)0.093
 Sever versus Absence0.275(0.150–0.506)<0.0010.615(0.318–1.888)0.148
 Mild versus Sever0.876(0.598–1.282)0.4950.965(0.649–1.435)0.860
Timing of CIN
 Early onset1 1 
 Non-early onset3.803(2.687–5.383)<0.0015.098(3.389–7.669)<0.001