Table 2 DEGs between DCISpure and DCIScomp and between invasive and noninvasive groups
From: Potential biomarkers of ductal carcinoma in situ progression
DEGs | Gene | t statistic | p value | FCa | |
|---|---|---|---|---|---|
DCISpure vs DCIScomp | Downregulated in DCISpure | IBSP | −3.86 | 8,00E-03 | −3.4 |
Upregulated in DCISpure | FGF2 | 4.16 | 4,00E-03 | 1.5 | |
GAS1 | 3.6 | 7,00E-03 | 2.67 | ||
LAMC3 | 4.11 | 2,00E-03 | 2.06 | ||
MAP3K8 | 3.49 | 8,00E-03 | 1.91 | ||
SFRP1 | 4.75 | 1,00E-03 | 2,61 | ||
Noninvasive vs invasive group | Downregulated in noninvasive group | ARID2 | −3.42 | 4,00E-03 | −1.52 |
BCL2L1 | −3.17 | 6,00E-03 | −1.7 | ||
BMP8A | −4.11 | 4,00E-04 | −2.28 | ||
CCNB1 | −3.12 | 5,00E-03 | −1.95 | ||
CDC25C | −3.16 | 4,00E-03 | −1.91 | ||
OSM | −3.11 | 5,00E-03 | −2.23 | ||
UTY | −3.1 | 5,00E-03 | −1.97 | ||
WHSC1 | −3.26 | 6,00E-03 | −1.46 | ||
Upregulated in noninvasive group | AXIN2 | 3 | 8,00E-03 | 2.14 | |
CNTFR | 2.95 | 9,00E-03 | 2.4 | ||
COL6A6 | 3.26 | 7,00E-03 | 3.75 | ||
DKK1 | 2.79 | 1,00E-02 | 2.02 | ||
DTX1 | 2.82 | 9,00E-03 | 1.76 | ||
EFNA5 | 3.21 | 4,00E-03 | 1.71 | ||
FGF10 | 3.26 | 3,00E-03 | 3.03 | ||
FGF2 | 3.73 | 2,00E-03 | 2.91 | ||
FGF7 | 3.71 | 1,00E-03 | 2.72 | ||
FOS | 2.8 | 1,00E-02 | 2.6 | ||
FZD7 | 3.3 | 4,00E-03 | 2.09 | ||
GAS1 | 3.67 | 1,00E-03 | 2.5 | ||
GLI3 | 3.11 | 5,00E-03 | 1.73 | ||
GRIA3 | 3.7 | 2,00E-03 | 2.88 | ||
IGF1 | 4.25 | 3,00E-04 | 2.72 | ||
IRS1 | 3.28 | 6,00E-03 | 2.05 | ||
ITGA9 | 3.55 | 2,00E-03 | 2.04 | ||
ITGB8 | 3.47 | 2,00E-03 | 2.83 | ||
JAK1 | 4.45 | 1,00E-04 | 1.32 | ||
JUN | 3.19 | 7,00E-03 | 2.51 | ||
KLF4 | 3.78 | 1,00E-03 | 2.4 | ||
LAMB3 | 2.9 | 1,00E-02 | 2.47 | ||
LAMC2 | 2.9 | 1,00E-02 | 2.14 | ||
LEPR | 4.43 | 3,00E-04 | 3.08 | ||
LIFR | 3 | 7,00E-03 | 2.16 | ||
MAP3K8 | 2.98 | 8,00E-03 | 1.56 | ||
MET | 4.09 | 4,00E-04 | 1.99 | ||
NGFR | 3.48 | 2,00E-03 | 2.49 | ||
NTRK2 | 3.32 | 4,00E-03 | 4.17 | ||
PDGFRA | 3.85 | 1,00E-03 | 2.01 | ||
PLD1 | 4.14 | 3,00E-04 | 1.81 | ||
PRKCA | 3.7 | 1,00E-03 | 1.89 | ||
PROM1 | 2.89 | 9,00E-03 | 3.68 | ||
RELN | 3.05 | 9,00E-03 | 3.25 | ||
SFRP1 | 4.01 | 5,00E-04 | 5.79 | ||
SOX17 | 3.84 | 8,00E-04 | 2.41 | ||
SOX9 | 3.01 | 6,00E-03 | 2.63 | ||
SRPY1 | 3.73 | 1,00E-03 | 2.15 | ||
SRPY2 | 3.47 | 3,00E-03 | 2.16 | ||
TCF7L1 | 3.23 | 4,00E-03 | 2.15 | ||
TGFBR2 | 3.9 | 7,00E-04 | 2.24 | ||
THEM4 | 2.86 | 9,00E-03 | 1.6 | ||
TNN | 3.47 | 2,00E-03 | 2.64 | ||
TSC1 | 2.83 | 9,00E-03 | 1.35 | ||
TSPAN7 | 3.61 | 1,00E-03 | 2.4 | ||