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Table 2 The “BRCAness” characteristic of ovarian tumors from TCGA database

From: An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

  1. HGSOC subtyping were taken from iAtlas ( P53 and PIK3CA mutation status were taken from cBioPortal (
  2. Genomic instability measures represent median values calculated for each subtype using data on individual samples taken from iAtlas. The values were considered positive for “BRCAness” (green cells) when they were equal or exceeded the threshold. The thresholds for P53 and PIK3CA mutation status represent the frequencies expressed by BRCA1 germline mutation carriers. The threshold for genomic instability measures represent the averaged value for all HGSOC subtypes: 33 for SNV neoantigens, 2.2 for non-silent mutation rate, 307.7 for Number of segments, 0.8 for the Fraction altered and 48.4 for HR recombination deficiency