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Fig. 5 | BMC Cancer

Fig. 5

From: An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

Fig. 5

Hereditary breast and ovarian cancers from the clinical trial and from TCGA database show high TMB and low overall immune activity relative to the sporadic tumors. Data obtained for our cohort (a, b), data acquired for TCGA breast (c-e) and ovarian (f-h) cancers. c and f) Somatic mutation count acquired from CBioPortal (http://www.cbioportal.org), d and g) Global immune gene expression representing averaged expression of genes from 28 meta-gene sets. Expression data was downloaded from FireBrowse data version 2016_01_28 (this link http://firebrowse.org/) e and h) Leukocyte fraction acquired from Cancer Research Institute iAtlas https://www.cri-iatlas.org/about/. The dotted lines indicate the average value for all the samples in each panel

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