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Table 3 Selected candidate mRNA-microRNA pairs

From: Integrative analysis of breast cancer profiles in TCGA by TNBC subgrouping reveals novel microRNA-specific clusters, including miR-17-92a, distinguishing basal-like 1 and basal-like 2 TNBC subtypes

microRNAmRNACorrelationLog2 Fold Change B1 vs B2TNBC Pro-Survival DirectionPredicted Binding
PCCadj. p-valuemiRNAmRNAmiRNAmRNAOrientationmRNA
hsa-mir-17IL1R1−0.561.17e-121.04−1.09DownUP3pIL1R1
hsa-mir-17INPP4B−0.554.21e-121.04−1.31DownUP3pINPP4B
hsa-mir-18aAPH1B−0.521.46e-100.98−0.55DownUP3p(APH1A)
hsa-mir-18aCPEB4−0.506.02e-100.98−0.83DownUP3p(CPEB1/3)
hsa-mir-18aFAM214A−0.521.00e-100.98−0.54DownUP3p(FAM214B)
hsa-mir-18aINPP4B−0.521.62e-100.98−1.31DownUP3pINPP4B
hsa-mir-18aKCNMA1−0.506.79e-100.98−1.04DownUP5pKCNMA1
hsa-mir-18aMAN2B2−0.541.17e-110.98−0.52DownUP3p(MAN2B1)
hsa-mir-18aTHSD4−0.527.80e-110.98−0.92DownUP3pTHSD4
hsa-mir-19aIL1R1−0.529.24e-110.87−1.09DownUP3p + 5pIL1R1
  1. mRNA-microRNA pairs computed by the integrative analysis combining correlation, differential expression, survival and target analysis. PCC Pearson correlation coefficient. Target mRNAs in parenthesis are paralogs of the investigated mRNAs