Table 2 Number of subjects with predicted transcriptionally active, intermediate or inactive p53 tetramer in each subgroup
Predicted activity of p53 tetramer based on DeltaNp53:TAp53 expression ratio | ||||||
|---|---|---|---|---|---|---|
Delta40p53:TAp53 | Delta133p53:TAp53 | |||||
ACT (P4w + P3w > 0.5) | INT | INACT (P1w + P0w > 0.5) | ACT (P4w + P3w > 0.5) | INT | INACT (P1w + P0w > 0.5) | |
Control (n = 4) | 1 | 1 | 2 | 3 | 1 | 0 |
Primary BCP-ALL (n = 40) | 30 | 6 | 4 | 32 | 6 | 2 |
hyperdiploid | 10 | 0 | 0 | 10 | 0 | 0 |
BCR-ABL1 | 4 | 3 | 3 | 4 | 4 | 2 |
ETV6-RUNX1 | 1 | 0 | 0 | 1 | 0 | 0 |
Others§ | 15 | 3 | 1 | 17 | 2 | 0 |
Relapse BCP-ALL (n = 10) | 3 | 4 | 3 | 5 | 3 | 2 |