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Table 1 Patient demographics and disease characteristics (N = 18)

From: Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors

CharacteristicsNo. of Patients%
Median age (range), y64 (34–79)N.A.
Sex
 Male1372.2
 Female527.8
Primary tumor location
 Stomach844.4
 Small bowel738.9
 Other316.7
Median tumor size (range), cm
 <5423.5
 5–10529.4
 >10847.1
Median mitotic count (/50HPF)
 <5642.8
 5–10428.6
 >10428.6
Primary mutation
 KIT exon 111477.8
 PDGFRA exon 12211.1
 PDGFRA exon 18211.1
Tumor dissemination
 Localized527.8
 Metastatic1372.2
Metastases location (n = 13)
 Liver969.2
 Peritoneum1077.0
 Other430.8
Median tumor burden metastatic disease, mm (range)a152 (26–289)N.A.
Sensitivity to imatinib
 Sensitive738.8
 Resistant1163.2
  1. aMedian tumor burden has been calculated as measurable disease at the initiation of treatment by RECIST criteria. Abbreviations: No. number, y years, N.A. not applicable, cm centimeters, HPF high-power fields, mm millimeters, TKI tyrosine kinase inhibitor