Table 1 Patient demographics and disease characteristics (N = 18)
Characteristics | No. of Patients | % |
|---|---|---|
Median age (range), y | 64 (34–79) | N.A. |
Sex | ||
Male | 13 | 72.2 |
Female | 5 | 27.8 |
Primary tumor location | ||
Stomach | 8 | 44.4 |
Small bowel | 7 | 38.9 |
Other | 3 | 16.7 |
Median tumor size (range), cm | ||
<5 | 4 | 23.5 |
5–10 | 5 | 29.4 |
>10 | 8 | 47.1 |
Median mitotic count (/50HPF) | ||
<5 | 6 | 42.8 |
5–10 | 4 | 28.6 |
>10 | 4 | 28.6 |
Primary mutation | ||
KIT exon 11 | 14 | 77.8 |
PDGFRA exon 12 | 2 | 11.1 |
PDGFRA exon 18 | 2 | 11.1 |
Tumor dissemination | ||
Localized | 5 | 27.8 |
Metastatic | 13 | 72.2 |
Metastases location (n = 13) | ||
Liver | 9 | 69.2 |
Peritoneum | 10 | 77.0 |
Other | 4 | 30.8 |
Median tumor burden metastatic disease, mm (range)a | 152 (26–289) | N.A. |
Sensitivity to imatinib | ||
Sensitive | 7 | 38.8 |
Resistant | 11 | 63.2 |