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Table 2 Frequency of bone complications

From: Bone complications in patients with multiple myeloma in five European countries: a retrospective patient chart review

OutcomeAt-risk periodaEU5b
N = 813
France
N = 146
Germany
N = 175
Italy
N = 173
Spain
N = 141
UK
N = 173
Patients who experienced at least one bone complication, n (%)c
 Any bone complicationOverall214 (26)40 (27)48 (27)49 (28)29 (21)43 (25)
Period 1135 (17)24 (16)28 (16)36 (21)19 (14)26 (15)
Period 267 (8)12 (8)18 (10)10 (6)5 (4)18 (10)
Period 372 (9)17 (12)17 (10)17 (10)9 (6)9 (5)
Mean number of bone complications per patient who experienced at least one bone complication, mean (95% CI)
 Any bone complicationOverall1.51 (1.41–1.61)1.43 (1.26–1.60)1.69 (1.45–1.93)1.47 (1.27–1.67)1.28 (1.00–1.56)1.56 (1.29–1.83)
Period 11.43 (1.32–1.55)1.46 (1.22–1.70)1.56 (1.28–1.83)1.33 (1.12–1.55)1.18 (0.95–1.41)1.54 (1.26–1.81)
Period 21.27 (1.11–1.43)1.21 (0.93–1.49)1.12 (0.96–1.27)1.33 (1.03–1.64)1.33 (0.80–1.87)1.42 (1.00–1.84)
Period 31.25 (1.12–1.38)1.19 (1.04–1.34)1.31 (0.94–1.69)1.31 (1.03–1.60)1.40 (0.97–1.83)1.20 (0.95–1.45)
Patients who experienced at least one bone complication by type of bone complication and at-risk period, n (%)d
 PFOverall137 (64)23 (58)34 (71)35 (71)23 (79)23 (54)
Period 199 (74)16 (67)22 (79)29 (81)18 (95)16 (62)
Period 219 (28)4 (33)3 (17)4 (40)1 (20)5 (28)
Period 340 (56)8 (47)12 (71)10 (59)6 (67)4 (44)
 SCCOverall29 (14)5 (13)8 (17)6 (12)2 (7)7 (16)
Period 121 (15)5 (21)3 (11)4 (11)2 (11)5 (19)
Period 25 (8)02 (11)003 (17)
Period 39 (13)1 (6)3 (18)3 (18)02 (22)
 RBOverall110 (51)21 (53)27 (56)18 (37)8 (28)29 (67)
Period 147 (35)11 (46)10 (36)7 (19)013 (50)
Period 244 (65)6 (50)11 (61)6 (60)4 (80)15 (83)
Period 331 (42)8 (47)6 (35)5 (29)5 (56)5 (56)
 SBOverall46 (22)8 (20)12 (25)13 (27)4 (14)8 (19)
Period 126 (19)2 (8)8 (29)8 (22)2 (11)6 (23)
Period 217 (25)4 (33)4 (22)3 (30)2 (40)3 (17)
Period 310 (13)3 (18)1 (6)4 (24)1 (11)0
  1. CI confidence interval, EU5 five European countries (France, Germany, Italy, Spain and the UK), PF pathologic fracture, RB radiation to bone, SB surgery to bone, SCC spinal cord compression, UK United Kingdom
  2. aOverall: from multiple myeloma diagnosis to disease progression following first-line treatment; period 1: before initiation of induction therapy; period 2: during active first-line therapy; period 3: after treatment discontinuation
  3. bAggregated EU5 data have been weighted based on the multiple myeloma incidence in each country so base sizes for individual countries may not equal the EU5 total
  4. cExpressed as a percentage of the total number of patients
  5. dExpressed as a percentage of the number of patients who experienced at least one bone complication