Outcome | At-risk perioda | EU5b N = 813 | France N = 146 | Germany N = 175 | Italy N = 173 | Spain N = 141 | UK N = 173 |
---|---|---|---|---|---|---|---|
Patients who experienced at least one bone complication, n (%)c | |||||||
 Any bone complication | Overall | 214 (26) | 40 (27) | 48 (27) | 49 (28) | 29 (21) | 43 (25) |
Period 1 | 135 (17) | 24 (16) | 28 (16) | 36 (21) | 19 (14) | 26 (15) | |
Period 2 | 67 (8) | 12 (8) | 18 (10) | 10 (6) | 5 (4) | 18 (10) | |
Period 3 | 72 (9) | 17 (12) | 17 (10) | 17 (10) | 9 (6) | 9 (5) | |
Mean number of bone complications per patient who experienced at least one bone complication, mean (95% CI) | |||||||
 Any bone complication | Overall | 1.51 (1.41–1.61) | 1.43 (1.26–1.60) | 1.69 (1.45–1.93) | 1.47 (1.27–1.67) | 1.28 (1.00–1.56) | 1.56 (1.29–1.83) |
Period 1 | 1.43 (1.32–1.55) | 1.46 (1.22–1.70) | 1.56 (1.28–1.83) | 1.33 (1.12–1.55) | 1.18 (0.95–1.41) | 1.54 (1.26–1.81) | |
Period 2 | 1.27 (1.11–1.43) | 1.21 (0.93–1.49) | 1.12 (0.96–1.27) | 1.33 (1.03–1.64) | 1.33 (0.80–1.87) | 1.42 (1.00–1.84) | |
Period 3 | 1.25 (1.12–1.38) | 1.19 (1.04–1.34) | 1.31 (0.94–1.69) | 1.31 (1.03–1.60) | 1.40 (0.97–1.83) | 1.20 (0.95–1.45) | |
Patients who experienced at least one bone complication by type of bone complication and at-risk period, n (%)d | |||||||
 PF | Overall | 137 (64) | 23 (58) | 34 (71) | 35 (71) | 23 (79) | 23 (54) |
Period 1 | 99 (74) | 16 (67) | 22 (79) | 29 (81) | 18 (95) | 16 (62) | |
Period 2 | 19 (28) | 4 (33) | 3 (17) | 4 (40) | 1 (20) | 5 (28) | |
Period 3 | 40 (56) | 8 (47) | 12 (71) | 10 (59) | 6 (67) | 4 (44) | |
 SCC | Overall | 29 (14) | 5 (13) | 8 (17) | 6 (12) | 2 (7) | 7 (16) |
Period 1 | 21 (15) | 5 (21) | 3 (11) | 4 (11) | 2 (11) | 5 (19) | |
Period 2 | 5 (8) | 0 | 2 (11) | 0 | 0 | 3 (17) | |
Period 3 | 9 (13) | 1 (6) | 3 (18) | 3 (18) | 0 | 2 (22) | |
 RB | Overall | 110 (51) | 21 (53) | 27 (56) | 18 (37) | 8 (28) | 29 (67) |
Period 1 | 47 (35) | 11 (46) | 10 (36) | 7 (19) | 0 | 13 (50) | |
Period 2 | 44 (65) | 6 (50) | 11 (61) | 6 (60) | 4 (80) | 15 (83) | |
Period 3 | 31 (42) | 8 (47) | 6 (35) | 5 (29) | 5 (56) | 5 (56) | |
 SB | Overall | 46 (22) | 8 (20) | 12 (25) | 13 (27) | 4 (14) | 8 (19) |
Period 1 | 26 (19) | 2 (8) | 8 (29) | 8 (22) | 2 (11) | 6 (23) | |
Period 2 | 17 (25) | 4 (33) | 4 (22) | 3 (30) | 2 (40) | 3 (17) | |
Period 3 | 10 (13) | 3 (18) | 1 (6) | 4 (24) | 1 (11) | 0 |