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Table 2 Frequency of bone complications

From: Bone complications in patients with multiple myeloma in five European countries: a retrospective patient chart review

Outcome At-risk perioda EU5b
N = 813
France
N = 146
Germany
N = 175
Italy
N = 173
Spain
N = 141
UK
N = 173
Patients who experienced at least one bone complication, n (%)c
 Any bone complication Overall 214 (26) 40 (27) 48 (27) 49 (28) 29 (21) 43 (25)
Period 1 135 (17) 24 (16) 28 (16) 36 (21) 19 (14) 26 (15)
Period 2 67 (8) 12 (8) 18 (10) 10 (6) 5 (4) 18 (10)
Period 3 72 (9) 17 (12) 17 (10) 17 (10) 9 (6) 9 (5)
Mean number of bone complications per patient who experienced at least one bone complication, mean (95% CI)
 Any bone complication Overall 1.51 (1.41–1.61) 1.43 (1.26–1.60) 1.69 (1.45–1.93) 1.47 (1.27–1.67) 1.28 (1.00–1.56) 1.56 (1.29–1.83)
Period 1 1.43 (1.32–1.55) 1.46 (1.22–1.70) 1.56 (1.28–1.83) 1.33 (1.12–1.55) 1.18 (0.95–1.41) 1.54 (1.26–1.81)
Period 2 1.27 (1.11–1.43) 1.21 (0.93–1.49) 1.12 (0.96–1.27) 1.33 (1.03–1.64) 1.33 (0.80–1.87) 1.42 (1.00–1.84)
Period 3 1.25 (1.12–1.38) 1.19 (1.04–1.34) 1.31 (0.94–1.69) 1.31 (1.03–1.60) 1.40 (0.97–1.83) 1.20 (0.95–1.45)
Patients who experienced at least one bone complication by type of bone complication and at-risk period, n (%)d
 PF Overall 137 (64) 23 (58) 34 (71) 35 (71) 23 (79) 23 (54)
Period 1 99 (74) 16 (67) 22 (79) 29 (81) 18 (95) 16 (62)
Period 2 19 (28) 4 (33) 3 (17) 4 (40) 1 (20) 5 (28)
Period 3 40 (56) 8 (47) 12 (71) 10 (59) 6 (67) 4 (44)
 SCC Overall 29 (14) 5 (13) 8 (17) 6 (12) 2 (7) 7 (16)
Period 1 21 (15) 5 (21) 3 (11) 4 (11) 2 (11) 5 (19)
Period 2 5 (8) 0 2 (11) 0 0 3 (17)
Period 3 9 (13) 1 (6) 3 (18) 3 (18) 0 2 (22)
 RB Overall 110 (51) 21 (53) 27 (56) 18 (37) 8 (28) 29 (67)
Period 1 47 (35) 11 (46) 10 (36) 7 (19) 0 13 (50)
Period 2 44 (65) 6 (50) 11 (61) 6 (60) 4 (80) 15 (83)
Period 3 31 (42) 8 (47) 6 (35) 5 (29) 5 (56) 5 (56)
 SB Overall 46 (22) 8 (20) 12 (25) 13 (27) 4 (14) 8 (19)
Period 1 26 (19) 2 (8) 8 (29) 8 (22) 2 (11) 6 (23)
Period 2 17 (25) 4 (33) 4 (22) 3 (30) 2 (40) 3 (17)
Period 3 10 (13) 3 (18) 1 (6) 4 (24) 1 (11) 0
  1. CI confidence interval, EU5 five European countries (France, Germany, Italy, Spain and the UK), PF pathologic fracture, RB radiation to bone, SB surgery to bone, SCC spinal cord compression, UK United Kingdom
  2. aOverall: from multiple myeloma diagnosis to disease progression following first-line treatment; period 1: before initiation of induction therapy; period 2: during active first-line therapy; period 3: after treatment discontinuation
  3. bAggregated EU5 data have been weighted based on the multiple myeloma incidence in each country so base sizes for individual countries may not equal the EU5 total
  4. cExpressed as a percentage of the total number of patients
  5. dExpressed as a percentage of the number of patients who experienced at least one bone complication