Skip to main content

Table 2 Molecular variant distribution of EGFR exon 19 deletion mutation

From: Differential significance of molecular subtypes which were classified into EGFR exon 19 deletion on the first line afatinib monotherapy

Type of mutation (Amino Acid)

Type of mutation (Nucleotide)

Number of nucleotide deletion

Frequency (n = 26)

COSMICa ID

Number of COSMIC registered samplesb

p.E746_A750delELREA

c.2235_2249del15 (Deletion)

15

13 (50.0%)

COSM6223

1106

p.E746_A750delELREA

c.2236_2250del15 (Deletion)

15

4 (15.4%)

COSM6225

528

p.E746_S752 > V

c.2237–2255 > T (complex)

Mixed ins/subc

2 (7.7%)

COSM12384

70

p.E746_T751 > I

c. 2235–2252 > AAT (complex)

Mixed ins/sub

1 (3.8%)

COSM13551

4

p.L747_T751delLREAT

c.2240_2254del15 (Deletion)

15

4 (15.4%)

COSM12369

134

p.L747_P753 > S

c.2240–2257 del18 (Deletion)

18

1 (3.8%)

COSM12370

174

p.S752_I759delSPKANKEI

c.2253–2276 del24 (Deletion)

24

1 (3.8%)

COSM13556

9

  1. athe Catalogue Of Somatic Mutations In Cancer, bAt 07/11/2018, cMixed insertion/substitution