Radiotherapy of prostate cancer: impact of treatment characteristics on the incidence of second tumors

BMC Cancer

Table 3 Multivariate analysis on second tumor free survival

Variable	value	pelvic		Pelvic-abdominal
Variable	value	HR	95%CI	p	HR	95%CI	p
Radiotherapy technique	3D-CRT	Ref
Radiotherapy technique	IMRT/VMAT	2.42	1.07–5.47	.034
Prophylactic nodal irradiation	No				Ref
Prophylactic nodal irradiation	Yes				1.63	0.95–2.79	.067
Combination of radiotherapy technique and irradiated volumes	3D-CRT without PNI	Ref			Ref
	IMRT/VMAT without PNI	1.70	0.53–5.51	.375	1.66	0.64–4.29	.294
	3D-CRT with PNI	1.10	0.27–4.46	.892	1.73	0.61–4.92	.303
	IMRT/VMAT with PNI	3.24	1.09–9.65	.035	2.61	1.06–6.41	.037

Legend: 3D-CRT three-dimensional conformal radiotherapy, IMRT Intensity modulated radiotherapy, PNI prophylactic nodal irradiation, VMAT volumetric modulated radiotherapy

ISSN: 1471-2407