Table 1 Factors significantly associated with breast LVI in univariable and multivariable logistic regression analysis using stepwise method
Variable | Univariable regression | Multivariable regression | ||
|---|---|---|---|---|
Odds Ratio (95%CI) | p-value | Odds Ratio (95%CI) | p-value | |
Margins | ||||
Well-defined | reference | reference | ||
Ill-defined | 4.99 (2.69–9.90) | < 0.001 | 3.46 (1.69–7.49) | 0.001 |
Lobulation sign | ||||
Absence | reference | reference | ||
Presence | 4.00 (2.38–6.89) | < 0.001 | 3.66 (1.90–7.30) | < 0.001 |
DWI appearance | ||||
Slight hyperintensity | reference | reference | ||
Marked hyperintensity | 3.46 (2.02–6.15) | < 0.001 | 2.67 (1.42–5.17) | 0.003 |
MRI-reported ALNM | ||||
Absence | reference | reference | ||
Single | 0.52 (0.26–1.04) | 0.068 | 0.33 (0.14–0.75) | 0.014 |
Multiple | 0.26 (0.15–0.45) | < 0.001 | 0.26 (0.13–0.51) | < 0.001 |
TIC type | ||||
I | reference | reference | ||
II | 12.16 (2.50–219.37) | 0.015 | 10.55 (1.87–201.14) | 0.032 |
III | 29.71 (5.55–553.11) | 0.001 | 26.00 (4.07–520.41) | 0.004 |
HER2 | ||||
- | reference | reference | ||
+ | 1.90 (0.61–7.24) | 0.298 | 1.24 (0.31–5.89) | 0.739 |
2+ | 2.76 (0.98–9.89) | 0.078 | 2.48 (0.70–10.92) | 0.195 |
3+ | 3.32 (1.11–12.41) | 0.046 | 6.37 (1.64–30.54) | 0.017 |