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Table 1 Study characteristics and demographics

From: Bidirectional treatment of peritoneal metastasis with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) and systemic chemotherapy: a systematic review

Author and publication year

Design

Malignancies

Number of patients

Number of patients with Bidirectional treatment

 

Gender (male/female)

Age, years (range or SD)

Previous tumor related surgery

Previous systemic chemotherapy

Alyami et al. 2017 [27]

Retrospective

Total

73

64

Total:

31/42

57.1 (32.3-77.9)d

NR

64

 - Gastric

26

NR

Bidirectional:

NR

NR

NR

NR

 - Colon

20

NR

     

 - Ovarian

13

NR

 - Mesothelioma

8

NR

 - Pseudomyxoma

1

NR

 - Others

5

NR

Demtröder et al. 2015 [28]

Retrospective

Colorectal

17

11

Total:

10/7

59 (+/-12)e

17

16

Bidirectional:

NR

NR

11

10

Falkenstein et al. 2018 [29]

Retrospective

Biliary tract

13

3

Total:

8/5

58 (37-75)f

9

7

Bidirectional:

NR

NR

NR

NR

Graversen et al. 2017 [30]

Prospective

Pancreatic

5

1

Total:

3/2

62 (49-69)g

2

5

Bidirectional:

0/1

62

0

1

Hilal et al. 2017 [31]

Retrospective

Total (all gynecological)

84

6

Total:

0/84

60.4 (+/-12.2)e

84i

84

 - Ovarian

77

NR

Bidirectional:

0/6

NR

6i

6

 - Fallopian tube

2

NR

     

 - Peritoneal

5

NR

Khomyakov et al. 2016 [24]

Prospective

Gastric

31

31

Total:

9/22

52 (25-70)f

NR

7

Bidirectional:

9/22

52 (25-70)f

NR

7

Khosrawipour et al. 2017 [32]

Retrospective

Pancreatic

20

6

Total:

15/5

64.9 (45-87)g

8

20

Bidirectional:

5/1

67.5 (52-75)g

3

6

Nadiradze et al. 2015 [33]

Retrospective

Gastric

24

8

Total:

12/12

56 (+/-13)e

14

19

Bidirectional:

NR

NR

NR

NR

Reymond et al. 2016 [34]a

Retrospective

Total

3

1b

Total:

1/2

68 (59-72)g

2

3

 - CUP

1

0

Bidirectional:

0/1

59

1

1

 - Pancreatic

1

0

     

 - Gallbladder

1

1

Robella et al. 2016 [26]

Retrospective

Total

14

13

Total:

NRc

52.5 (39-78)g

9

14

 - Mesothelioma

2

1

Bidirectional:

NRc

52 (39-78)g

8

13

 - Ovarian

3

3

     

 - Colorectal

2

2

 - Pseudomyxoma

1

1

 - Gastric

6

6

Farinha et al. 2017 [35]

Retrospective

Total

42

1

Total:

8/34

66 (59-73)h

NR

NR

 - Gynecological

21

NR

Bidirectional:

NR

NR

NR

NR

 - CRC

14

NR

     

 - Gastric

3

NR

 - Small bowel

1

NR

 - Appendix

1

NR

 - Pseudomyxoma

1

NR

 - Mesothelioma

1

NR

Hübner et al. 2017 [36]

Retrospective

Total

60

NR

Total:

NR

NR

NR

NR

 - Gynecological

NR

NR

Bidirectional:

NR

NR

NR

NR

 - Digestive

NR

NR

     
  1. CUP cancer of unknown primary, NR not reported
  2. aIncluding conventional PIPAC and Electrostatic Precipitation PIPAC (ePIPAC)
  3. bAuthors stated that all patients received concomitant systemic chemotherapy. Following our definition two patients did not receive bidirectional therapy since systemic chemotherapy was terminated before the first PIPAC procedure
  4. cIncluding three gynecological cancers – all receiving bidirectional treatment
  5. dMedian with range
  6. eMean with Standard Deviation
  7. fMean with range
  8. gCalculated median with range
  9. hMedian with Inter-Quartile Range
  10. iThis study concerned relapse of cancer and patients were interpreted as having had primary surgery
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BMC Cancer

ISSN: 1471-2407

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