Fig. 2

Schematic representation of the STEREO-HBM study. *Each targeted brain metastasis (hemorrhagic or not) will be treated at the dose of 30 Gy in 3 fractions at 10 Gy per fraction every 2 days. All target lesions (maximum 3 brain metastases plus one tumor bed) will be treated as much as possible over 1 week. However, cerebral irradiation of all the lesions may be spread over 7–10 calendar days. **Standard MRI imaging protocol plus optional multivoxel spectroscopy imaging (MSI) only for voluntary patients with specific signed informed consent. Abbreviation: FSRT hypofractionated stereotactic radiotherapy; MRI Magnetic Resonance Imaging. *Each targeted brain metastasis (hemorrhagic or not) will be treated at the dose of 30 Gy in 3 fractions at 10 Gy per fraction every 2 days. All target lesions (maximum 3 brain metastases plus one tumor bed) will be treated as much as possible over 1 week. However, cerebral irradiation of all the lesions may be spread over 7–10 calendar days. **Standard MRI imaging protocol plus optional multivoxel spectroscopy imaging (MSI) only for voluntary patients with specific signed informed consent. Abbreviation: FSRT hypofractionated stereotactic radiotherapy; MRI Magnetic Resonance Imaging