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Table 2 Univariate analyses, multivariate analyses of preoperative prognostic factors influencing cancer-specific survival outcomes in the training cohort

From: Development and validation of a preoperative nomogram for predicting survival of patients with locally advanced prostate cancer after radical prostatectomy

Variable

Univariate analyses (KM) p-value

Univariate analyses (CIF) p-value

Multivariate Cox regression analyses HR (95%CI)

P-value

Multivariate Competing risk analyses sdHR (95%CI)

P-value

Age

0.041

0.047

    

 < 50

  

Ref.

 

Ref.

 

 50–59

  

1.111 (0.440–2.804)

0.824

1.110 (0.440–2.802)

0.826

 60–69

  

0.805 (0.321–2.0203)

0.645

0.803 (0.320–2.015)

0.641

 > 69

  

1.291 (0.495–3.373)

0.602

1.284 (0.492–3.355)

0.609

Race

0.860

0.852

    

 White

  

Ref.

 

Ref.

 

 Black

  

0.988 (0.587–1.661)

0.962

0.987 (0.587–1.661)

0.962

 Other

  

0.961 (0.487–1.898)

0.908

0.960 (0.486–1.897)

0.907

Marital Status

0.790

0.815

    

 Married

  

Ref.

 

Ref.

 

 Single

  

1.004 (0.675–1.495)

0.984

1.003 (0.674–1.493)

0.988

 Unknown

  

1.193 (0.602–2.364)

0.613

1.189 (0.600–2.357)

0.619

T stage

0.300

0.304

    

 T1–2

  

Ref.

 

Ref.

 

 T3–4

  

6.511 (0.897–47.269)

0.064

6.493 (0.895–47.142)

0.064

N stage

< 0.001

< 0.001

    

 N0

  

Ref.

 

Ref.

 

 N1

  

2.431 (1.695–3.489)

< 0.001

2.429 (1.693–3.483)

< 0.001

PSA level (ng/ml)

< 0.001

< 0.001

    

 ≤ 10

  

Ref.

 

Ref.

 

 10–20

  

1.141 (0.765–1.702)

0.519

1.140 (0.764–1.701)

0.521

 > 20

  

1.472 (0.962–2.253)

0.075

1.473 (0.962–2.253)

0.075

GS biopsy

< 0.001

< 0.001

    

 ≤ 6

  

Ref.

 

Ref.

 

 7 (3 + 4)

  

4.252 (1.277–14.152)

0.018

4.253 (1.2779–14.157)

0,018

 7 (4 + 3)

  

6.096 (1.827–20.338)

0.003

6.099 (1.828–20.349)

0.003

 8

  

9.796 (2.972–32.286)

< 0.001

9.8068 (2.975–32.322)

< 0.001

 ≥ 9

  

18.879 (5..88–61.576)

< 0.001

18.888 (5.791–61.605)

< 0.001

% positive core biopsy

< 0.001

< 0.001

    

 00–25%

  

Ref.

 

Ref.

 

 25–50%

  

1.099 (0.599–2.018)

0.760

1.100 (0.599–2.020)

0.758

 50–75%

  

1.145 (0.604–2.173)

0.678

1.145 (0.604–2.173)

0.678

 75–100%

  

2.176 (1.219–3.8837)

0.009

2.174 (1.218–3.881)

0.009

  1. Abbreviation: KM Kaplan-Meier method, CIF Cumulative incidence function, sdHR Subdistribution hazard ratio, Ref. Reference, % positive core biopsy Percent of positive cores at biopsy
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