Fig. 4

Mutational profiles of total SNVs, GOH or LOH in 110-Liver cohorts, along with Signatures α and β resolved from the total SNV profile. (a) WGS SNV mutations; (b) Exome-subset mutations; and (c) AluScan-subset mutations. All profiles were displayed using the 96-trinucleotide contexts where the mutated base was flanked by the 3′ and 5′ neighboring bases. The frequency bars represent the numbers of six types of substitution mutations, viz. C > A, C > G, C > T, T > A, T > C and T > G. Inverted arrows above the bars were typical of Signature α where mutations at NCG trinucleotides constituted the tallest peaks in the C > T or T > C boxes