Fig. 1

Relative numbers of GOH and LOH identified from mapped WGS data for 110 tumor-blood paired samples from Japanese liver cancer patients including 85 HCC, 18 ICC and 7 HCC/ICC, and survival analysis based on the SNV load. Numbers of GOH (green) and LOH (orange) were shown for (a) all 110 samples; (b) 49 samples with total SNV less than 6000; and (c) 35 samples with total SNV more than 20,000. Linear regression lines with respective coefficient of determination (r²) calculated from Pearson’s r statistic were shown for GOH in (B) and for LOH in (C). The relative numbers of GOH and LOH in the Exome-subset and AluScan-subset are given in Additional File 1: Table S2. (d) Comparison of the numbers of SNVs in the WGSs of 85-HCC and 25-ICCG (18 ICC + 7 HCC/ICC) using student’s t-test. Kaplan-Meier survival plots for two survival-probability subgroups in 110 liver cancer patients (e) and 85 HCC patients (f) stratified based on the numbers of SNVs in their WGSs (upper panels), Exome-subset (middle panels), and AluScan-subset (lower panels). Number of death out of the total number of patients in each group was shown in the parentheses. Censored patients were indicated by the tic marks on the survival curves. The optimal cut-point of SNV load employed to divide the patients into two subgroups was identified as the cut-point yielding the lowest p-value in the log-rank test (see ‘Patient stratification for survival analysis’ in Methods)