PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas

BMC Cancer

Table 5 Univariate and multivariate analyses of prognostic factors for OS

	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
High PD-L1 expression in TCs	0.40	0.21–0.76	0.0050	0.43	0.22–0.85	0.014
High PD-L1 expression in TICs	2.25	1.12–4.54	0.023	0.76	0.31–1.82	0.53
High density of PD-1⁺ TICs	1.71	0.85–3.46	0.13	–	–	–
High VEGF expression in TCs	2.14	0.94–4.85	0.07	–	–	–
High density of CD4⁺ TICs	0.32	0.16–0.65	0.0015	0.31	0.15–0.67	0.0025
High density of CD8⁺ TICs	0.31	0.096–1.01	0.053	–	–	–
High density of CD68⁺ TICs	1.58	0.79–3.12	0.19	–	–	–
Age > 60	2.81	1.47–5.36	0.0017	1.36	0.68–2.72	0.39
FIGO stage III/IV (vs. I/II)	8.62	4.26–17.4	2.0E-09	5.50	2.43–12.5	0.000042
Non-endometrioid (vs. Endometrioid)	5.78	2.99–11.2	1.9E-07	3.31	1.50–7.32	0.0031
MI > 1/2	5.04	2.50–10.2	6.4E-06	1.46	0.66–3.19	0.35
LVI (+)	3.75	1.92–7.34	0.00011	2.27	1.09–4.73	0.028

Abbreviations: OS overall survival, HR hazard ratio, CI confidence interval, PD-L1 programmed cell death-ligand 1, TCs tumor cells, TICs tumor-infiltrating immune cells, PD-1 programmed cell death-1, VEGF vascular endothelial growth factor, FIGO International Federation of Gynecology and Obstetrics, MI myometrial invasion, LVI lymphovascular space invasion

ISSN: 1471-2407