Table 3 Mutual relationships among TME protein expressions
From: PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas
| Â | PD-L1 in TICs | Â | PD-1+ TICs | Â | VEGF in TCs | Â | CD4+ TICs | Â | CD8+ TICs | Â | CD68+ TICs | Â | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | High expression (n = 36) | Low expression (n = 185) | P-value | High density (n = 131) | Low density (n = 90) | P-value | High expression (n = 151) | Low expression (n = 70) | P-value | High density (n = 117) | Low density (n = 104) | P-value | High density (n = 43) | Low density (n = 178) | P-value | High density (n = 129) | Low density (n = 92) | P-value |
High PD-L1 expression in TCs | 18 (50%) | 137 (74%) | 0.0054 | 88 (67%) | 67 (74%) | 0.30 | 102 (68%) | 53 (76%) | 0.27 | 86 (74%) | 69 (66%) | 0.30 | 33 (77%) | 122 (69%) | 0.36 | 88 (68%) | 67 (73%) | 0.55 |
High PD-L1 expression in TICs | – | – | – | 31 (24%) | 5 (6%) | 0.00032 | 29 (19%) | 7 (10%) | 0.12 | 24 (21%) | 12 (12%) | 0.10 | 19 (44%) | 17 (10%) | 6.4E-07 | 30 (23%) | 6 (7%) | 0.00078 |
High density of PD-1+ TICs | – | – | – | – | – | – | 86 (57%) | 45 (64%) | 0.38 | 76 (65%) | 55 (53%) | 0.076 | 33 (77%) | 98 (55%) | 0.0097 | 90 (70%) | 41 (45%) | 0.00028 |
High VEGF expression in TCs | – | – | – | – | – | – | – | – | – | 76 (65%) | 75 (72%) | 0.31 | 33 (77%) | 118 (66%) | 0.21 | 88 (68%) | 63 (68%) | 1.0 |
High density of CD4+ TICs | – | – | – | – | – | – | – | – | – | – | – | – | 32 (74%) | 85 (48%) | 0.0020 | 77 (60%) | 40 (43%) | 0.020 |
High density of CD8+ TICs | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 32 (25%) | 11 (12%) | 0.024 |