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Table 2 Optimal cut-off values of IHC scores for the relationship with OS

From: PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas

 

Mean ± SD

Min

Max

Cut-off

Category

N (%)

PD-L1 in TCs

1.36 ± 1.47

0

9

0<

High expression

155 (70)

Low expression

66 (30)

PD-L1 in TICs

2.70 ± 1.94

0

9

4<

High expression

36 (16)

Low expression

185 (84)

PD-1+ TICs

16.94 ± 23.55

0

129.33

6.67<

High density

131 (59)

Low density

90 (41)

VEGF in TCs

3.64 ± 1.69

1

9

2<

High expression

151 (68)

Low expression

70 (32)

CD4+ TICs

137.99 ± 65.18

31

391

126.33<

High density

117 (53)

Low density

104 (47)

CD8+ TICs

196.52 ± 121.71

18.33

582.67

296.33<

High density

43 (19)

Low density

178 (81)

CD68+ TICs

161.61 ± 88.00

16.33

527.67

126<

High density

129 (58)

Low density

92 (42)

  1. Abbreviations: IHC immunohistochemical, OS overall survival, SD standard deviation, Min minimum, Max maximum, PD-L1 programmed cell death-ligand 1, TCs tumor cells, TICs tumor-infiltrating immune cells, PD-1 programmed cell death-1, VEGF vascular endothelial growth factor