Table 2 The top 5 enriched GO terms of the DEGs
Category | GO ID | GO Term | Count | FDR | Log P | Genes |
|---|---|---|---|---|---|---|
Biological Process | 0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 8 | 1.62E-14 | −16.8846 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, HLA-DQA1, HLA-DRA |
Biological Process | 0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 9 | 5.29E-11 | −13.369 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA |
Biological Process | 0019882 | antigen processing and presentation | 7 | 3.03E-08 | −10.6113 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, CD74, HLA-DQA1, HLA-DRA |
Biological Process | 0006955 | immune response | 10 | 3.29E-07 | −9.57522 | HLA-DQB1, CD86, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA |
Biological Process | 0002503 | peptide antigen assembly with MHC class II protein complex | 4 | 1.52E-05 | −7.91138 | HLA-DRB4, HLA-DMB, HLA-DMA, HLA-DRA |
Cellular Component | 0042613 | MHC class II protein complex | 9 | 2.13E-16 | −18.6699 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA |
Cellular Component | 0071556 | integral component of lumenal side of endoplasmic reticulum membrane | 6 | 1.41E-07 | −9.84824 | HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA |
Cellular Component | 0005765 | lysosomal membrane | 9 | 4.03E-07 | −9.39244 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA |
Cellular Component | 0030658 | transport vesicle membrane | 6 | 5.93E-07 | −9.2251 | HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA |
Cellular Component | 0030669 | clathrin-coated endocytic vesicle membrane | 6 | 8.83E-07 | −9.05199 | HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA |
Molecular Function | 0032395 | MHC class II receptor activity | 7 | 5.72E-12 | −14.2221 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DOA, HLA-DMA, HLA-DQA1, HLA-DRA |
Molecular Function | 0023026 | MHC class II protein complex binding | 5 | 2.47E-06 | −8.58782 | HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DRA |
Molecular Function | 0042605 | peptide antigen binding | 5 | 2.75E-05 | −7.54062 | HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DQA1, HLA-DRA |
Molecular Function | 0004051 | arachidonate 5-lipoxygenase activity | 2 | 2.237376 | −2.62558 | ALOX5AP, ALOX5 |