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Table 2 The top 5 enriched GO terms of the DEGs

From: Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis

CategoryGO IDGO TermCountFDRLog PGenes
Biological Process0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II81.62E-14−16.8846HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, HLA-DQA1, HLA-DRA
Biological Process0019886antigen processing and presentation of exogenous peptide antigen via MHC class II95.29E-11−13.369HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA
Biological Process0019882antigen processing and presentation73.03E-08−10.6113HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, CD74, HLA-DQA1, HLA-DRA
Biological Process0006955immune response103.29E-07−9.57522HLA-DQB1, CD86, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA
Biological Process0002503peptide antigen assembly with MHC class II protein complex41.52E-05−7.91138HLA-DRB4, HLA-DMB, HLA-DMA, HLA-DRA
Cellular Component0042613MHC class II protein complex92.13E-16−18.6699HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA
Cellular Component0071556integral component of lumenal side of endoplasmic reticulum membrane61.41E-07−9.84824HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA
Cellular Component0005765lysosomal membrane94.03E-07−9.39244HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DQA1, HLA-DRA
Cellular Component0030658transport vesicle membrane65.93E-07−9.2251HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA
Cellular Component0030669clathrin-coated endocytic vesicle membrane68.83E-07−9.05199HLA-DQB1, HLA-DRB4, HLA-DPA1, CD74, HLA-DQA1, HLA-DRA
Molecular Function0032395MHC class II receptor activity75.72E-12−14.2221HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DOA, HLA-DMA, HLA-DQA1, HLA-DRA
Molecular Function0023026MHC class II protein complex binding52.47E-06−8.58782HLA-DMB, HLA-DOA, HLA-DMA, CD74, HLA-DRA
Molecular Function0042605peptide antigen binding52.75E-05−7.54062HLA-DQB1, HLA-DRB4, HLA-DPA1, HLA-DQA1, HLA-DRA
Molecular Function0004051arachidonate 5-lipoxygenase activity22.237376−2.62558ALOX5AP, ALOX5