Table 1 Patient Characteristics by 70-GS Result
From: MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial
Patient Characteristics | 70-GS Result | |||
|---|---|---|---|---|
Age (yrs) | Low Risk (n = 224) | High Risk (n = 134) | Total (n = 358) | p- value |
median | 62 | 62 | p = 0.388 | |
mean | 61.4 | 60.0 | ||
Clinical Risk | ||||
Low Risk | 160 (70.5%) | 67 (20.5%) | 227 | p < 0.0001 |
High Risk | 64 (48.9%) | 67 (51.1%) | 131 | |
Menopausal Status | ||||
Post | 173 (63.8%) | 98 (36.2%) | 271 | p = 0.632 |
Pre/Peri | 45 (60.8%) | 29 (39.2%) | 74 | |
Unknown | 6 (46.2%) | 7 (53.8%) | 13 | |
Tumor Stage | ||||
T1 (all) | 179 (64.6%) | 98 (35.4%) | 277 | p = 0.585 |
T1a | 15 (62.5%) | 9 (37.5%) | 24 | |
T1b | 59 (65.6%) | 31 (34.4%) | 90 | |
T1c | 96 (63.6%) | 55 (36.4%) | 151 | |
T2 | 44 (55.0%) | 36 (45.0%) | 80 | |
T3 | 1 (100%) | 0 (0%) | 1 | |
Nodal Status | ||||
N0 | 173 (62.2%) | 105 (37.8%) | 278 | p = 0.896 |
N1 | 51 (63.8%) | 29 (36.3%) | 80 | |
Grade | ||||
G1: Low grade | 85 (85.0%) | 15 (15.0%) | 100 | p < 0.0001 |
G2: Intermediate grade | 122 (63.5%) | 70 (36.5%) | 192 | |
G3: High grade | 14 (22.2%) | 49 (77.8%) | 63 | |
GX: Unknown | 3 (100%) | 0 (0%) | 3 | |
Tumor Type | ||||
Invasive ductal carcinoma (IDC) | 161 (59.4%) | 110 (40.6%) | 271 | p = 0.032 |
Invasive lobular carcinoma (ILC) | 41 (80.4%) | 10 (19.6%) | 51 | |
IDC/ILC | 5 (5.0%) | 5 (50.0%) | 10 | |
Other | 17 (65.4%) | 9 (34.6%) | 26 | |
Ethnicity | ||||
African/Black | 23 (67.6%) | 11 (32.4) | 34 | p = 0.603 |
Caucasian/White | 181 (63.1%) | 106 (36.9%) | 287 | |
Hispanic | 10 (50.0%) | 10 (50.0%) | 20 | |
Other | 10 (58.8%) | 7 (41.2%) | 17 | |
PR Status (IHC) | ||||
IHC Negative | 11 (32.4%) | 23 (67.6%) | 34 | p = 0.0003 |
IHC Positive | 212 (65.5%) | 111 (34.5%) | 323 | |
Unknown | 1 (100%) | 0 (0%) | 1 | |