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Table 5 Univariate and multivariate analyses of clinicopathologic parameters associated with overall survival

From: The prognostic value of neuromedin U in patients with hepatocellular carcinoma

Clinical parametersUnivariate analysisMultivariate analysis
HR95% CIP valueHR95% CIP value
Sex (male vs. female)0.7260.410–1.2850.271   
Age (yrs) (≤60 vs. >60)0.9910.661–1.4840.964   
HCC family history (yes vs. no)0.7100.313–1.6090.412   
HBsAg (positive vs. negative)0.9060.538–1.5250.710   
Cirrhosis (yes vs. no)1.0550.704–1.5810.795   
Tumor number (single vs. multiple)2.5451.808–3.582<0.001   
Tumor size (cm) (≤5 vs. >5)2.8181.894–4.192<0.001   
Major vascular invasion (yes vs. no)2.8691.967–4.184<0.001   
Edmondson grade (I + II vs. III + IV)1.7111.181–2.4790.0051.7181.179–2.5040.005
TNM stage (I + II vs. III + IV)3.8512.739–5.413<0.0013.3032.320–4.702<0.001
Child-Pugh class (A vs. B)1.8131.041–3.1590.036   
PLT count (×109) (≥100 vs. <100)2.2541.103–4.6030.026   
TBIL (μmol/L) (<34.2 vs. ≥34.2)1.3940.787–2.4700.255   
ALT (U/L) (≤40 vs. >40)1.5171.001–2.2990.049   
AST (U/L) (≤37 vs. >37)3.2652.261–4.716<0.0012.4071.628–3.559<0.001
AFP (ug/L) (≤20 vs. >20)1.3290.887–1.9920.168   
NMU peri-tumor (low vs. high group)1.6911.211–2.3610.0021.5411.092–2.1750.014
NMU intra-tumor (low vs. high group)1.2290.879–1.7200.228   
  1. Abbreviations: HR hazard ratio, CI confidence interval, HCC hepatocellular carcinoma, HBsAg hepatitis B surface antigen, TNM tumor-node- metastasis, PLT platelet, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, AFP a-fetoprotein, NMU neuromedin U. It was considered to have significance when a value of p was < 0.05