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Table 4 Univariate and multivariate analyses of clinicopathologic parameters associated with disease-free survival

From: The prognostic value of neuromedin U in patients with hepatocellular carcinoma

Clinical parametersUnivariate analysisMultivariate analysis
HR95% CIP valueHR95% CIP value
Sex (male vs. female)0.9140.560–1.4920.720   
Age (yrs) (≤60 vs. >60)1.0920.765–1.5580.630   
HCC family history (yes vs. no)1.2180.642–2.3090.546   
HBsAg (positive vs. negative)0.7030.425–1.1620.169   
Cirrhosis (yes vs. no)0.9160.635–1.3200.636   
Tumor number (single vs. multiple)2.1631.569–2.981<0.001   
Tumor size (cm) (≤5 vs. >5)2.3551.670–3.320<0.0011.5511.065–2.2580.022
Major vascular invasion (yes vs. no)2.5101.743–3.617<0.001   
Edmondson grade (I + II vs. III + IV)1.5841.118–2.2440.0101.5141.067–2.1490.020
TNM stage (I + II vs. III + IV)3.0772.240–4.225<0.0012.4841.767–3.494<0.001
Child-Pugh class (A vs. B)1.8461.112–3.0630.0181.7891.064–3.0080.028
PLT count (×109) (≥100 vs. <100)2.6231.338–5.1410.005   
TBIL (μmol/L) (<34.2 vs. ≥34.2)1.3730.819–2.3010.229   
ALT (U/L) (≤40 vs. >40)1.2810.867–1.8940.214   
AST (U/L) (≤37 vs. >37)2.3281.643–3.299<0.0011.7751.225–2.5720.002
AFP (ug/L) (≤20 vs. >20)1.2180.850–1.7440.282   
NMU peri-tumor (low vs. high group)1.3741.012–1.8650.041   
NMU intra-tumor (low vs. high group)1.1790.867–1.6040.294   
  1. Abbreviations: HR hazard ratio, CI confidence interval, HCC hepatocellular carcinoma, HBsAg hepatitis B surface antigen, TNM tumor-node- metastasis, PLT platelet, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, AFP a-fetoprotein, NMU neuromedin U. It was considered to have significance when a value of p was < 0.05