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Table 3 Relationship between NMU expression and 16 clinicopathological features

From: The prognostic value of neuromedin U in patients with hepatocellular carcinoma

VariablesCasesNMU expression (peri-tumor)P valueNMU expression (intra-tumor)P value
LowHighLowHigh
Sex
 Male203121(59.6%)82(40.4%)0.267123(60.6%)80(39.4%)0.658
 Female2512(48.0%)13(52.0%) 14(56.0%)11(44.0%) 
Age (yrs)
  ≤ 60179106(59.2%)73(40.8%)0.605111(62%)68(38%)0.257
 >604927(55.1%)22(44.9%) 26(53.1%)23(46.9%) 
HCC family history
 Yes1310(76.9%)3(23.1%)0.16210(76.9%)3(23.1%)0.202
 No215123(57.2%)92(42.8%) 127(59.1%)88(40.9%) 
HBsAg
 Positive201121(60.2%)80(39.8%)0.119119(59.2%)82(40.8%)0.457
 Negative2712(44.4%)15(55.6%) 18(66.7%)9(33.3%) 
Cirrhosis
 Yes180107(59.4%)73(40.6%)0.510108(60.0%)72(40.0%)0.958
 No4826(54.2%)22(45.8%) 29(60.4%)19(39.6%) 
Tumor number
 Single16190(55.9%)71(44.1%)0.22892(57.1%)69(42.9%)0.159
 Multiple6743(64.2%)24(35.8%) 45(67.2%)22(32.8%) 
Tumor size (cm)
  ≤ 58150(61.7%)31(38.3%)0.44042(51.9%)39(48.1%)0.059
 >514783(56.5%)64(43.5%) 95(64.6%)52(35.4%) 
Major vascular invasion
 Yes4223(54.8%)19(45.2%)0.60328(66.7%)14(33.3%)0.335
 No186110(59.1%)76(40.9%) 109(58.6%)77(41.4%) 
Edmondson grade
 I-II177101(57.1%)76(42.9%)0.468105(59.3%)72(40.7%)0.660
 III-IV5132(62.7%)19(37.3%) 32(62.7%)19(37.3%) 
TNM stage
 I-II15188(58.3%)63(41.7%)0.98187(57.6%)64(42.4%)0.286
 III-IV7745(58.4%)32(41.6%) 50(64.9%)2735.1%) 
Child-Pugh class
 A210125(59.5%)85(40.5%)0.213127(60.5%)83(39.5%)0.682
 B188(44.4%)10(55.6%) 10(55.6%)8(44.2%) 
PLT count (× 109)
  ≥ 100206120(58.3%)86(41.7%)0.940123(59.7%)83(40.3%)0.721
 <1002213(59.1%)9(40.9%) 14(63.6%)8(36.4%) 
TBIL (μmol/L)
 <34.2210126(60.0%)84(40.0%)0.081129(61.4%)81(38.6%)0.158
  ≥ 34.2187(38.9%)11(61.1%) 8(44.4%)10(55.6%) 
ALT (U/L)
  ≤ 40190115(60.5%)75(39.5%)0.133111(58.4%)79(41.6%)0.251
 >403818(47.4%)20(52.6%) 26(68.4%)12(31.6%) 
AST (U/L)
 ≤37179111(62.0%)68(38.0%)0.031106(59.2%)73(40.8%)0.608
 >374922(44.2%)27(55.1%) 31(63.3%)18(36.7%) 
AFP (ug/L)
  ≤ 205529(52.7%)26(47.3%)0.33332(58.2%)23(41.8%)0.740
 >20173104(60.1%)69(39.9%) 105(60.7%)68(39.3%) 
  1. Abbreviations: HCC hepatocellular carcinoma, HBsAg hepatitis B surface antigen, TNM tumor-node- metastasis, PLT platelet, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, AFP a-fetoprotein. It was considered to have significance when a value of p was < 0.05