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Fig. 5 | BMC Cancer

Fig. 5

From: IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα− BCa and AR− PCa cells and promotes cell survival

Fig. 5

Regulatory Networks generated using IPA and 350 gene signature. IPA predicts regulatory networks based on gene expression patterns and the published literature available in the IPA database. a Interactome of p62 identified using Upstream Regulator Analysis of IPA (z-score = 2.449, p-value = 8.38E-05). p62 is predicted to activate expression of CXCL2, IL15RA, IRF1, PLAT, RGCC, and RSAD2. b Interactome of SOX9 identified using IPA (IPA does not report SOX9 as an upstream regulator). SOX9 is predicted to activate VNN1 expression and mediate FN1 and T-Cell Factor (TCF) signaling. c Mechanistic Network identified using IPA where p62 is a master regulator (bias-corrected p-value = 8.00E-03). p62 is predicted to activate HIF1A, NFκB1, NFKBIA, NFκB (complex), RELA, and SQSTM1(p62) signaling and regulate the activation of IL-1β signaling and the inhibition of NR3C1 function

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BMC Cancer

ISSN: 1471-2407

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