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Table 4 The diagnostic sensitivity and specificity of CTC and CEA in patients with upper lobe, subsolid and ≥ 8-mm nodules. (N = 37)

From: The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

Diagnostic method

Cutoff point

Sensitivity (%)

Specificity (%)

Youden Index value

AUC (95% CI)

CTC (units)

12

51.85

90.00

0.419

0.700 (0.527–0.839)

CEA (ng/ml)

1.78

62.96

80.00

0.429

0.681 (0.508–0.825)

CTC + CEA

12 /1.78

77.80

90.00

0.478

0.733 (0.566–0.900)

  1. CTC circulating tumour cell; CEA carcinoembryonic antigen