Immunogenomic pathways associated with cytotoxic lymphocyte infiltration and survival in colorectal cancer

BMC Cancer

Table 2 Differentially expressed genes in the “Immunoregulatory interactions between a lymphoid and a non-lymphoid cell” pathway associated with survival grouped by pathologic stage, cytotoxic lymphocyte (CL) status, and anatomical location

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Location	Stages	CLs Status	Gene Symbol	P-value
Right	Early (I,II)	High	RAET1E	0.033
			LILRA1	0.031
			CD33	0.018
		Low	N/A
	Localized (I,II,III)	High	RAET1E	0.013
			LILRA1	0.0087
			LILRA4	0.042
			CD33	0.017
		Low	KLRC1	0.027
	Metastasis (IV)	High	MADCAM1	0.046
			FCGR2B(CD32)	0.046
			SIGLEC8(CD329)	0.046
			CLEC4G	0.046
		Low	CD96	0.027
			LILRB1	0.015
			ITGB2(CD18)	0.033
			CD40LG	0.029
			C3	0.018
			SIGLEC9	0.0071
			SH2D1A	0.027
			LAIR1(CD305)	0.0043
			CD300A	0.0043
Left	Early	High	N/A
	Early	Low	KLRC1	0.025
	Localized	High	N/A
	Localized	Low	N/A
	Metastasis	High	N/A
	Metastasis	Low	CLEC2B	0.046
Rectum	Early	High	N/A
	Early	Low	CLEC4G	0.046
	Localized	High	N/A
		Low	HCST	0.019
			FCGR1A(CD64)	0.039
			CLEC4G	0.022
	Metastasis	High	N/A
	Metastasis	Low	N/A

CLs Cytotoxic lymphocytes; gene symbols with bold font indicate positive impact on patient’s survival, gene symbols with italic font indicate negative impact on patient’s survival

ISSN: 1471-2407