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Fig. 2 | BMC Cancer

Fig. 2

From: Immunogenomic pathways associated with cytotoxic lymphocyte infiltration and survival in colorectal cancer

Fig. 2

Pathway Enrichment analysis based on tumor location and stage. Pathway enrichment was ranked using a composite of the adjusted p value for false discovery rate (color) and gene ratio (size). a pathway enrichment for early stage CRC (Stage I and II) based on location; b pathway enrichment analysis for localized CRC (Stages I-III) based on location; c pathway enrichment analysis for metastatic stage CRC (Stage IV) based on location. This analysis showed that the “immunoregulatory interactions between a lymphoid and a non-lymphoid cell” was the most highly enriched pathway in early and local patients at all sites. Additionally, this was the most highly enriched pathway in patients with metastatic right-sided cancer. This pathway was also among the top pathways enriched among patients with metastatic left-sided colon cancer and rectal cancer. (Input data included in Additional file 2)

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