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Table 4 Factors associated with recurrence free survival in the patients of LS and SCRC group (univariate and multivariate analysis)

From: Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: a propensity score matching analysis

Variable N. patients N. eventsa Univariate analysis Multivariate analysis
Total 141 35 χ2 p value Risk ratio (95% CI) p value
Sex    1.173 0.314   
 Male 80 21     
 Female 61 14     
Age
 < 50 103 26 0.092 0.762   
 ≥50 38 9     
CEA    0.220 0.639   
 < 5.2 118 28     
 ≥5.2 23 7     
Etiology    1.260 0.262   
 Lynch syndrome 47 9     
 Sporadic CRC 94 26     
Location    2.018 0.569   
 Right colon 58 11     
 Left colon 61 17     
 Rectal 16 5     
 Multiple 6 2     
Pathological classification    19.274 < 0.001 1.345(0.865–2.090) 0.188
 Adenocarcinoma 105 24     
 Partial mucinous 16 0     
 Mucinous adenocarcinoma 20 11     
Differentiation grade    7.260 0.027 0.761(0.343–1.689) 0.502
 Well 2 0     
 Moderately 84 15     
 Poorly 55 20     
Cancerous node    12.595 < 0.001 3.011(1.067–8.498) 0.037
 Occurrence 9 6     
 Absence 132 29     
Vascular invasion    43.571 < 0.001 0.236(0.109–0.512) < 0.001
 Occurrence 29 21     
 Absence 112 14     
Perineural invasion    13.654 < 0.001 1.552(0.679–3.546) 0.297
 Occurrence 21 15     
 Absence 120 20     
TNM stage    52.055 < 0.001 2.841(1.619–4.986) < 0.001
 I 40 1     
 II 47 8     
 III 46 19     
 IV 8 7     
KRAS    0.007 0.934   
 Wild type 71 16     
 Variant type 70 19     
NRAS    0.368 0.544   
 Wild type 136 33     
 Variant type 5 2     
  1. CEA Carcinoembryonic antigen, LS Lynch syndrome, SCRC Sporadic colorectal cancer, N. Number, CI Confidence interval, CRC Colorectal cancer
  2. aEvents refers to tumor recurrence of primary CRC