Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: a propensity score matching analysis

Table 4 Factors associated with recurrence free survival in the patients of LS and SCRC group (univariate and multivariate analysis)

Variable	N. patients	N. events^a	Univariate analysis		Multivariate analysis
Total	141	35	χ²	p value	Risk ratio (95% CI)	p value
Sex			1.173	0.314
Male	80	21
Female	61	14
Age
< 50	103	26	0.092	0.762
≥50	38	9
CEA			0.220	0.639
< 5.2	118	28
≥5.2	23	7
Etiology			1.260	0.262
Lynch syndrome	47	9
Sporadic CRC	94	26
Location			2.018	0.569
Right colon	58	11
Left colon	61	17
Rectal	16	5
Multiple	6	2
Pathological classification			19.274	< 0.001	1.345(0.865–2.090)	0.188
Adenocarcinoma	105	24
Partial mucinous	16	0
Mucinous adenocarcinoma	20	11
Differentiation grade			7.260	0.027	0.761(0.343–1.689)	0.502
Well	2	0
Moderately	84	15
Poorly	55	20
Cancerous node			12.595	< 0.001	3.011(1.067–8.498)	0.037
Occurrence	9	6
Absence	132	29
Vascular invasion			43.571	< 0.001	0.236(0.109–0.512)	< 0.001
Occurrence	29	21
Absence	112	14
Perineural invasion			13.654	< 0.001	1.552(0.679–3.546)	0.297
Occurrence	21	15
Absence	120	20
TNM stage			52.055	< 0.001	2.841(1.619–4.986)	< 0.001
I	40	1
II	47	8
III	46	19
IV	8	7
KRAS			0.007	0.934
Wild type	71	16
Variant type	70	19
NRAS			0.368	0.544
Wild type	136	33
Variant type	5	2

CEA Carcinoembryonic antigen, LS Lynch syndrome, SCRC Sporadic colorectal cancer, N. Number, CI Confidence interval, CRC Colorectal cancer
^aEvents refers to tumor recurrence of primary CRC

ISSN: 1471-2407