Fig. 1

Adhesion G protein-coupled receptors (adhesion-GPCR) gene microarray profiling in human retinoblastomas (Rb). a Expression data from the Childhood Solid Tumor Network at St Jude Children’s Research Hospital containing the RNA expression of 31 members of the adhesion-GPCR orphan receptors were analyzed in 11 fetal retinae compared to 64 Rb tumor samples. b Hierarchical cluster analysis show three clusters of adhesion-GPCRs in normal fetal retinae and Rb tissue samples. c, d Box and whiskers plots display significant upregulation of ELTD1 in Rb tumors compared to fetal retinae, (p < 0.0001) but no difference is detected in the RNA expression of GPR125 (p = 0.1731)