Fig. 3

Different stages of early gastric neoplasia according to the depth of invasion (total magnification = 100x & 200x, scale = 100 & 200 μm). Hematoxylin and Eosin staining. (A1/A2) Gastric high grade dysplasia displaying complex glandular structure, significant cellular atypia, nuclear pseudo-stratification, hyperchromasia and poor nuclear polarization. (B1/B2) Cancer invading lamina propria. (C1/C2) Invasion involving the muscularis mucosae layer. (D1/D2) Gastric cancer that infiltrates into the submucosal layer but less than 500 μm depth from the muscularis mucosae, there is also associated lymphatic invasion. (E1/E2) Submucosal invasion greater than 500 μm from the muscularis mucosae with positive vertical margin