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Fig. 3 | BMC Cancer

Fig. 3

From: Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

Fig. 3

Antitumor effect of BNCT in murine MBT2 tumor-bearing mice. a-f Tumor growth curves from the following treatment groups: (a) untreated control (cold control, blue dashed line); (b) IF7C(10BPA)RR injection (cold IF7C(10BPA)RR, red dashed line); (c) IF7K(10BSH)RR injection (cold IF7K(10BSH)RR, black dashed line); (d) Neutron-irradiation (hot control, blue solid line); (e) IF7C(10BPA)RR-mediated BNCT (hot IF7C(10BPA)RR, red solid line); and (f) IF7K(10BSH)RR-mediated BNCT (hot IF7K(10BSH)RR, black solid line). Groups were intravenously injected, and tumors irradiated with epi/thermal neutrons 40 min after injection on day 1. g Tumor growth curve comparing groups analyzed in A-F. Results are expressed as means ± SD. *P < 0.05 (Holm–Sidak method). N.S.: no significant difference. h Body weight of indicated groups. Results are expressed as means ± SD. i Tumor weight of indicated groups at sacrifice. Results are expressed as violin plots with dot plots. Red bold lines indicate the median value, while red dashed lines indicate the interquartile range value (Mann–Whitney test) (j) Photograph of resected tumors from the injected right thighs. If a tumor completely shrank, whole right thighs were resected and labeled as “no tumor”

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