Table 1 Patient characteristics and their prognostic impact on overall survival
Characteristics | N = 72 | OS (months) | HR (95% CI) | p-valuea |
|---|---|---|---|---|
Age, years | ||||
Median | 62.4 | – | – | – |
Range | 30–83 | |||
Sex, n (%) | ||||
Male | 33 (45.8) | 9.4 | 1.317 (0.8–2.2) | 0.308 |
Female | 39 (54.2) | 12.8 | ||
ECOG PS, n (%) | ||||
0–1 | 52 (72.2) | 11.9 | 0.632 (0.3–1.2) | 0.161 |
2–3 | 20 (27.8) | 7.1 | ||
Tumor location, n (%) | ||||
Right-sided | 35 (48.6) | 10.6 | – | 0.296 |
Left-sided | 22 (30.6) | 11.3 | ||
Rectum | 15 (20.8) | 13.1 | ||
Histological grade, n (%) | ||||
Low grade (G1–2) | 37 (51.4) | 11.9 | 0.895 (0.5–1.7) | 0.723 |
High grade (G3) | 23 (31.9) | 11.1 | ||
Unknown | 12 (16.7) | |||
Mismatch repair proteins, n (%) | n=33 | |||
Conserved | 31 (93.1) | 12.8 | 0.146 (0.1–0.8) | 0.010 |
Deficiency | 2 (6.9) | 4.9 | ||
Tumor presentation, n (%) | ||||
Synchronous | 50 (69.4) | 12.4 | 0.903 (0.5–1.6) | 0.730 |
Metachronous | 22 (30.6) | 5.9 | ||
Primary tumor surgery, n (%) | ||||
No | 25 (34.7) | 9.6 | 1.932 (1.1–3.4) | 0.023 |
Yes | 47 (65.3) | 11.9 | ||
Metastasectomy, n (%) | ||||
No | 57 (79.2) | 9.6 | 2.307 (1.2–4.6) | 0.011 |
Yes | 15 (20.8) | 19.6 | ||