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Table 3 Univariate and multivariate Cox regression analysis of overall survival in 86 patients after CRS+HIPEC

From: High-grade postoperative complications affect survival outcomes of patients with colorectal Cancer peritoneal metastases treated with Cytoreductive surgery and Hyperthermic Intraperitoneal chemotherapy

Variables Overall survival
Univariate analysis Multivariate analysis
HR(95%CI) P HR(95%CI) P
Gender: male/female 1.21 (0.68–2.18) 0.517   
Age at operation 1.01 (0.99–1.04) 0.400   
Preoperative chemotherapy (no/yes) 0.79 (0.40–1.55) 0.489   
Synchronous/metachronous 0.80 (0.44–1.47) 0.476   
Site of original (colon/rectum) 2.13 (1.16–3.92) 0.015 1.71 (0.913–3.20) 0.094
Histology (adenocarcinoma/mucinous) 1.65 (0.92–3.00) 0.096   
Preoperative CEA level 1.00 (0.99–1.01) 0.161   
Preoperative CA19–9 level 1.00 (0.99–1.01) 0.342   
Liver metastases (no/yes) 1.36 (0.67–2.74) 0.397   
HIPEC regimen (lobaplatin/non-lobaplatin) 1.60 (0.87–2.95) 0.134   
Presence of ascites (no/yes) 1.34 (0.74–2.40) 0.335   
PCI score 1.01 (1.05–1.15) < 0.001 1.07 (1.01–1.14) 0.015
CC score (0–1/2–3) 3.36 (1.85–6.08) < 0.001 1.92 (0.96–3.83) 0.064
Grade 3–4 Postoperative complication (no/yes) 2.71 (1.48–4.94) 0.001 1.86 (1.22–3.51) 0.044
Leukopenia (no/yes) 1.31 (0.61–2.83) 0.487   
Neutropenia (no/yes) 1.31 (0.47–3.70) 0.605   
Thrombocytopenia (no/yes) 1.45 (0.80–2.66) 0.224