|
Weibull parameters
|
|
Scale (λ) for PFS
|
0.034827
|
0.069115
|
[19]
|
|
Shape (γ) for PFS
|
1.486146
|
1.468545
|
[19]
|
|
Scale (λ) for OS
|
0.007118
|
0.007698
|
[19]
|
|
Shape (γ) for OS
|
1.676228
|
1.867383
|
[19]
|
|
Survival
|
|
Median OS (range), month
|
13.6 (11.5–17.5)
|
11.0 (9.2–12.9)
|
[19]
|
|
Median imaging PFS (range), month
|
8.0 (5.7–9.2)
|
3.7 (2.8–5.1)
|
[19]
|
|
Median PFS (range), month
|
4.4 (3.6–5.4)
|
2.7 (2.4–2.8)
|
[19]
|
|
Treatment
|
|
Median treatment duration (range), month
|
22 (3–88)
|
12.5 (2–141)
|
[19]
|
|
Median treatment cycles
|
7 (1–29)
|
4 (1–45)
|
[19]
|
|
Probability of AEs (grade 3/4)
|
|
Musculoskeletal pain or discomfort
|
0.016 (0.013–0.019)
|
0.056 (0.045–0.067)
|
[19]
|
|
Renal disorder
|
0.032 (0.026–0.038)
|
0.081 (0.065–0.097)
|
[19]
|
|
Anemia
|
0.080 (0.064–0.096)
|
0.048 (0.038–0.058)
|
[19]
|
|
Leukopenia
|
0.320 (0.256–0.384)
|
0.016 (0.013–0.019)
|
[19]
|
|
Neutropenia
|
0.447 (0.358–0.536)
|
0.032 (0.026–0.038)
|
[19]
|
|
Utility
|
|
PFS
|
0.617 (0.494–0.740)
|
0.617 (0.494–0.740)
|
[22]
|
|
PD
|
0.370 (0.296–0.444)
|
0.370 (0.296–0.444)
|
[22]
|
