| No.of studies | No.of patients | Pooled HR (95%CI) | Meta regression p-value | Heterogeneity | ||
---|---|---|---|---|---|---|---|
Fixed | Random | Â | I2 | p-value | |||
Overall | 18 | 1691 | 1.600 (1.44–1.77) | 1.86 (1.52–2.28) |  | 58.7% | 0.001 |
Ethnicity | Â | Â | Â | Â | 0.806 | Â | Â |
 Asian | 15 | 1456 | 1.58 (1.42–1.76) |  1.82 (1.48–2.24) |  | 55.2% | 0.005 |
 Caucasian | 3 | 235 | 1.86 (1.25–2.76) | 2.20 (0.90–5.37) |  | 78.6% | 0.009 |
Sample Size | Â | Â | Â | Â | 0.979 | Â | Â |
  ≥ 100 | 7 | 937 | 1.51 (1.34–1.69) | 1.61 (1.35–1.92) |  | 36.1% | 0.153 |
 <100 | 11 | 754 | 1.98 (1.59–2.48) | 2.00 (1.37–2.93) |  | 63.2% | 0.002 |
NOS Scores | Â | Â | Â | Â | 0.978 | Â | Â |
  ≥ 8 | 11 | 1100 | 1.53 (1.36–1.71) | 1.75 (1.42–2.16) |  | 49.5% | 0.031 |
  < 8 | 7 | 591 | 2.00 (1.56–2.55) | 1.87 (1.20–2.93) |  | 65.8% | 0.008 |
Specimen | Â | Â | Â | Â | 0.933 | Â | Â |
 tissue | 17 | 1532 | 1.57 (1.41–1.75) | 1.87 (1.50–2.33) |  | 60.2% | 0.001 |
 plasma | 1 | 159 | 1.88 (1.34–2.63) | 1.88 (1.34–2.63) |  | – | – |
Cancer Types | Â | Â | Â | Â | 0.494 | Â | Â |
 EC | 2 | 210 | 1.69 (1.04–2.74) | 1.87 (0.88–4.00) |  | 45.6% | 0.175 |
 GC | 5 | 457 | 1.33 (1.13–1.57) | 1.25 (0.59–2.65) |  | 68.3% | 0.013 |
 HCC | 4 | 339 | 1.60 (1.33–1.92) | 1.84 (1.30–2.59) |  | 48.7% | 0.119 |
 PC | 4 | 460 | 2.27 (1.77–2.89) | 2.59 (1.69–3.97) |  | 57.1% | 0.072 |
 CRC | 2 | 148 | 1.59 (1.03–2.47) | 1.59 (1.03–2.47) |  | 0.0% | 0.556 |
 GBC | 1 | 77 | 2.37 (1.11–5.06) | 2.37 (1.11–5.06) |  | – | – |