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Table 3 Association between miR-34a expression levels and overall survivals

From: Prognostic value of low microRNA-34a expression in human gastrointestinal cancer: a systematic review and meta-analysis

 

No.of studies

No.of patients

Pooled HR (95%CI)

Meta regression p-value

Heterogeneity

Fixed

Random

 

I2

p-value

Overall

18

1691

1.600 (1.44–1.77)

1.86 (1.52–2.28)

 

58.7%

0.001

Ethnicity

    

0.806

  

 Asian

15

1456

1.58 (1.42–1.76)

 1.82 (1.48–2.24)

 

55.2%

0.005

 Caucasian

3

235

1.86 (1.25–2.76)

2.20 (0.90–5.37)

 

78.6%

0.009

Sample Size

    

0.979

  

  ≥ 100

7

937

1.51 (1.34–1.69)

1.61 (1.35–1.92)

 

36.1%

0.153

 <100

11

754

1.98 (1.59–2.48)

2.00 (1.37–2.93)

 

63.2%

0.002

NOS Scores

    

0.978

  

  ≥ 8

11

1100

1.53 (1.36–1.71)

1.75 (1.42–2.16)

 

49.5%

0.031

  < 8

7

591

2.00 (1.56–2.55)

1.87 (1.20–2.93)

 

65.8%

0.008

Specimen

    

0.933

  

 tissue

17

1532

1.57 (1.41–1.75)

1.87 (1.50–2.33)

 

60.2%

0.001

 plasma

1

159

1.88 (1.34–2.63)

1.88 (1.34–2.63)

 

–

–

Cancer Types

    

0.494

  

 EC

2

210

1.69 (1.04–2.74)

1.87 (0.88–4.00)

 

45.6%

0.175

 GC

5

457

1.33 (1.13–1.57)

1.25 (0.59–2.65)

 

68.3%

0.013

 HCC

4

339

1.60 (1.33–1.92)

1.84 (1.30–2.59)

 

48.7%

0.119

 PC

4

460

2.27 (1.77–2.89)

2.59 (1.69–3.97)

 

57.1%

0.072

 CRC

2

148

1.59 (1.03–2.47)

1.59 (1.03–2.47)

 

0.0%

0.556

 GBC

1

77

2.37 (1.11–5.06)

2.37 (1.11–5.06)

 

–

–

  1. Abbreviations: 95%CI 95% confidence interval, CRC colorectal cancer, EC esophageal cancer, GBC gallbladder cancer, GC gastric cancer, HCC hepatocellular carcinoma, HR hazard ratio, NOS Newcastle-Ottawa Scale, PC pancreatic cancer