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Fig. 6 | BMC Cancer

Fig. 6

From: The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

Fig. 6

The DNA methylation level and mRNA expression of Sonic Hedgehog signaling components of MSCs exposed to R-2HG during osteogenic differentiation. a. Methylation levels of SHH signaling genes in R-2HG treated and control MSCs from two donors. b. Expression of SHH signaling genes were detected by quantitative RT-PCR. Data are presented as mean ± S.D. and performed in triplicate from an experiment representative of three independent experiments. *P < 0.05 vs. the group of MSCs in absence of R-2HG. ** P < 0.01 vs. the group of MSCs in absence of R-2HG

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