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Table 4 Expression of cellular markers in normal cervix, SIL, and cervical cancer

From: TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions

  NSIL LSIL   HSIL   CC   
n = 79 % n = 208 % n = 35 % n = 42 % p
p16INK4a
 Negative 33 41.8 0 0.0 0 0.0 0 0.0 < 0.001
 Mild 29 36.7 7 3.4 1 2.9 0 0.0  
 Moderate 11 13.9 168 80.8 6 17.1 0 0.0  
 Intense 6 7.6 33 15.9 28 80.0 42 100  
Ki-67
 Negative 33 41.8 2 1.0 0 0.0 0 0.0 < 0.001
 Mild 28 35.4 26 12.5 2 5.7 0 0.0  
 Moderate 18 22.8 165 79.3 8 22.9 0 0.0  
 Intense 0 0.0 15 7.2 25 71.4 42 100  
Cyclin E
 Negative 36 45.6 1 0.5 0 0.0 0 0.0 < 0.001
 Mild 27 34.2 17 8.2 0 0.0 0 0.0  
 Moderate 13 16.4 170 81.7 14 40.0 0 0.0  
 Intense 3 3.8 20 9.6 21 60.0 42 100  
TOP2A/MCM2
 Negative 42 53.2 0 0.0 0 0.0 0 0.0 < 0.001
 Mild 25 31.6 20 9.6 0 0.0 0 0.0  
 Moderate 11 13.9 179 86.1 11 31.4 0 0.0  
 Intense 1 1.3 9 4.3 24 68.6 42 100  
Telomerase
 Negative 28 35.4 1 0.5 0 0.0 0 0.0 < 0.001
 Mild 31 39.2 8 3.8 0 0.0 0 0.0  
 Moderate 19 24.1 124 59.6 8 22.9 0 0.0  
 Intense 1 1.3 75 36.1 27 77.1 42 100  
ROS
 Q1 38 29.5 38 17.9 5 17.2 17 53.1 < 0.001
 Q2 45 34.9 37 17.5 9 31.1 10 31.3  
 Q3 30 23.2 55 25.9 12 41.4 4 12.5  
 Q4 16 12.4 82 38.7 3 10.3 1 3.1  
8-OHdG
 Q1 63 67.7 11 6.5 5 19.2 0 0 < 0.001
 Q2 23 24.7 40 23.5 6 23.1 12 37.5  
 Q3 4 4.3 67 39.4 5 19.2 5 15.6  
 Q4 3 3.2 52 30.6 10 38.5 15 46.9  
  1. NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer; 8-OHdG and ROS levels are expressed as quartiles, Q1-Q4. Interquartile range
  2. P values were calculate using X2 test