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Table 2 Prevalence of single, multiple, and mixed-HPV infections in cervix without SIL, with SIL and CC

From: TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions

 

NSIL

LSIL

HSIL

CC

n = 239

%

n = 901

%

n = 54

%

n = 291

%

HPV negative

74

30.9

1

0.1

0

0.0

5

1.7

HPV positive

165

69.1

900

99.9

54

100

286

98.3

Single HPV infection

 HR

61

25.5

231

25.6

17

31.5

190

65.3

 PHR

16

6.8

78

8.7

3

5.7

2

0.7

 LR

19

7.9

95

10.5

0

0.0

2

0.7

 UR

25

10.6

148

16.4

4

7.4

51

17.6

Total

121

50.8

552

61.2

24

44.6

245

84.3

Multiple HPV infection

 HR

5

2.1

65

7.2

10

18.5

20

7.0

 PHR

1

0.4

11

1.2

0

0.0

0

0.0

 LR

1

0.4

7

0.8

1

1.8

2

0.7

 UR

1

0.4

6

0.7

1

1.8

0

0.0

Total

8

3.3

89

9.9

12

22.1

22

7.7

Mixed HPV infection

 HR and PHR

11

4.6

66

7.4

4

7.5

1

0.3

 HR and LR

11

4.6

86

9.5

6

11.1

13

4.5

 HR and UR

2

0.8

18

2.0

4

7.5

1

0.3

 PHR and LR

4

1.7

26

2.9

1

1.8

1

0.3

 PHR and UR

2

0.8

10

1.2

0

0.0

1

0.3

 LR and UR

0

0.0

8

0.9

0

0.0

1

0.3

 HR, PHR, and LR

4

1.7

31

3.4

0

0.0

1

0.3

 HR, PHR, and UR

0

0.0

4

0.4

1

1.8

0

0.0

 HR, LR, and UR

1

0.4

7

0.8

1

1.8

0

0.0

 PHR, LR, and UR

1

0.4

0

0.0

0

0.0

0

0.0

 HR, PHR, LR, and UR

0

0.0

3

0.3

1

1.8

0

0.0

Total

36

15.0

259

28.8

18

33.3

19

6.3

  1. NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer, HR High risk, PHR Probably high risk, LR Low risk, UR Undeterminate risk, Single HPV Infection with one genotype, Multiple HPV Infection with two genotypes of the same-risk group, Mixed HPV Infection with genotypes of different oncogenic risk groups