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Table 2 Prevalence of single, multiple, and mixed-HPV infections in cervix without SIL, with SIL and CC

From: TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions

  NSIL LSIL HSIL CC
n = 239 % n = 901 % n = 54 % n = 291 %
HPV negative 74 30.9 1 0.1 0 0.0 5 1.7
HPV positive 165 69.1 900 99.9 54 100 286 98.3
Single HPV infection
 HR 61 25.5 231 25.6 17 31.5 190 65.3
 PHR 16 6.8 78 8.7 3 5.7 2 0.7
 LR 19 7.9 95 10.5 0 0.0 2 0.7
 UR 25 10.6 148 16.4 4 7.4 51 17.6
Total 121 50.8 552 61.2 24 44.6 245 84.3
Multiple HPV infection
 HR 5 2.1 65 7.2 10 18.5 20 7.0
 PHR 1 0.4 11 1.2 0 0.0 0 0.0
 LR 1 0.4 7 0.8 1 1.8 2 0.7
 UR 1 0.4 6 0.7 1 1.8 0 0.0
Total 8 3.3 89 9.9 12 22.1 22 7.7
Mixed HPV infection
 HR and PHR 11 4.6 66 7.4 4 7.5 1 0.3
 HR and LR 11 4.6 86 9.5 6 11.1 13 4.5
 HR and UR 2 0.8 18 2.0 4 7.5 1 0.3
 PHR and LR 4 1.7 26 2.9 1 1.8 1 0.3
 PHR and UR 2 0.8 10 1.2 0 0.0 1 0.3
 LR and UR 0 0.0 8 0.9 0 0.0 1 0.3
 HR, PHR, and LR 4 1.7 31 3.4 0 0.0 1 0.3
 HR, PHR, and UR 0 0.0 4 0.4 1 1.8 0 0.0
 HR, LR, and UR 1 0.4 7 0.8 1 1.8 0 0.0
 PHR, LR, and UR 1 0.4 0 0.0 0 0.0 0 0.0
 HR, PHR, LR, and UR 0 0.0 3 0.3 1 1.8 0 0.0
Total 36 15.0 259 28.8 18 33.3 19 6.3
  1. NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer, HR High risk, PHR Probably high risk, LR Low risk, UR Undeterminate risk, Single HPV Infection with one genotype, Multiple HPV Infection with two genotypes of the same-risk group, Mixed HPV Infection with genotypes of different oncogenic risk groups