Table 2 Top pathways of miRNA targets predicted by mirDIP analysis

Direct p53 effectors

2,54E-14

TRRAP,SERPINE1,CREBBP,CASP10,SERPINB5,HTT,IGFBP3,HIC1,MCL1

TNFRSF10C,TNFRSF10B,TNFRSF10D,BCL6,SP1,MDM2,BCL2L1,PTEN

APAF1,MET,TP53INP1,E2F1,BAK1,PML,APC,CCNK,EPHA2,LIF,SMARCA4

TP73,PRMT1,FOXA1,EP300,HGF,TSC2,NDRG1,CAV1,VCAN

Signaling by Interleukins

2,54E-14

FRS2,GATA3,HIF1A,PSMF1,IL22RA1,COL1A2,JAK2,DUSP6,DUSP7,NRAS

ALOX5,STAT6,STAT1,STAT3,DAB2IP,CSF1,IRS2,RORA,FGF1,SQSTM1

HSP90B1,SOCS3,SOCS1,MCL1,KL,BCL6,NF1,BCL2L1,FLT3,KSR1,NRG1

TNFRSF1B,PIK3CA,MET,CRK,NOD2,ANGPT1,CRKL,SOX2,BTRC,AKAP9

STAT5B,LIF,PTK2,SMARCA4,GRB2,SYK,OSMR,IL1A,KIT,RHOU,MAP3K3

OSM,CCND1,HGF,LIFR,POU2F1,IL7,FGFR1,CXCL2,MMP9,YWHAZ,CBL

ERBB4,PTK2B,MAPK1,NCAM1,CAMK2G,KRAS

PI3K-Akt signaling pathway

5,83E-13

AKT2,MYB,PRKCA,NGFR,COL1A2,JAK2,NRAS,CSF1,FGF1,HSP90B1,BCL2L11

MCL1,CDK6,MDM2,BCL2L1,FLT1,ITGB3,PTEN,PIK3CG,VWF,ITGA2,PIK3CA

ITGA6,MET,EIF4E,ANGPT1,PPP2R1B,EPHA2,LPAR1,LPAR3,PTK2,GRB2

BRCA1,SYK,OSMR,KIT,SGK1,RXRA,OSM,IGF1R,CCND2,CCND1,HGF,TSC2

TSC1,IL7,FGFR1,PDPK1,YWHAZ,RBL2,LAMA4,THBS2,THBS1,MAPK1,KRAS

Generic Transcription Pathway

5,83E-13

SERPINE1,GLS,MED1,BARD1,CREBBP,NR2F1,CASP10,TEAD1,NCOR2,NCOR1

RARA,PPARA,RICTOR,RORA,CTGF,YY1,IGFBP3,NOTCH2,NOTCH1,TNFRSF10C

TNFRSF10B,ESRRG,TNFRSF10D,BCL6,SP1,MDM2,PIN1,PTEN,APAF1,GLS2

TP53INP1,E2F1,E2F4,PML,CCNK,CCNC,CHEK1,RUNX2,ATM,TP73,BRCA1

NCOA2,PRMT1,KIT,SGK1,RXRA,NR3C1,EP300,TSC2,TSC1,FANCD2,NDRG1

SMAD2,TFAP2A,TFAP2C,SMAD4,SMAD3,ESR1,NR4A3,THRB,PDPK1,YWHAZ

RBL2,RBL1,NR2C1,MTA2,MAPK14,MAPK11

FoxO signaling pathway

5,83E-13

AKT2,CREBBP,PLK1,NRAS,STAT3,IRS2,BCL2L11,BCL6,MDM2,PTEN,PIK3CG

PIK3CA,CSNK1E,GRB2,ATM,PRMT1,SGK1,IGF1R,CCND2,CCND1,EP300

SMAD2,SMAD4,TGFB2,SMAD3,PDPK1,TGFBR1,RBL2,MAPK8,MAPK1

MAPK14,MAPK10,MAPK11,KRAS

Hippo signaling pathway

6,85E-11

SERPINE1,PRKCZ,FZD1,TEAD1,WNT7A,FGF1,CTGF,DVL1,NF2,BMPR2,APC

SOX2,RASSF1,PPP2R1B,BTRC,CSNK1E,TP73,CTNNB1,WWC1,CCND2,CCND1

WNT5A,SMAD2,SMAD4,TGFB2,SMAD3,BMP6,DLG1,AXIN2,YWHAZ,TGFBR1

LATS1,TCF7L2

Regulation of nuclear

2,51E-06

SERPINE1,GATA3,CREBBP,COL1A2,NCOR1,CBFB,SP1,RUNX3,RUNX2,RUNX1

SMAD2/3 signalin

NCOA2,NR3C1,EP300,SMAD2,SMAD4,SMAD3,ESR1