| Univariate | Multivariate | ||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age, ≥65 vs < 65 | 0.49 (0.20–1.18) | 0.1115 |  |  |
Gender, Female vs. Male | 0.35 (0.10–1.24) | 0.1039 |  |  |
ECOG, 2 ~ 3 vs. 0 ~ 1 | 10.67 (0.93–122.33) | 0.0572 | 6.39 (0.48–8575) | 0.1613 |
Smoking (pack.year), ≥20 vs. < 20 | 2.75 (0.97–7.75) | 0.0563 | 5.62 (1.59–19.78) | 0.0072 |
PD-L1 expression > 1 vs ≤1 | 0.28 (0.12–0.68) | 0.0049 | 0.35 (0.13–0.93) | 0.0355 |
Oncogenic driver mutation, any one vs. no | 3.14 (1.17–8.39) | 0.0227 | 3.21 (0.97–10.60) | 0.0552 |
EGFR mutation, positive vs. negative | 2.32 (0.74–7.27) | 0.1483 |  |  |
No. of metastatic site, ≥3 vs. < 3 | 3.74 (1.43–9.79) | 0.0073 | 3.53 (1.13–10.99) | 0.0297 |
No. of treatment line before IO, ≥4 vs. < 4 | 2.30 (0.73–7.21) | 0.1526 |  |  |