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Table 1 Patients’ clinical characteristics according to tumor response pattern (n = 155)a

From: The implications of clinical risk factors, CAR index, and compositional changes of immune cells on hyperprogressive disease in non-small cell lung cancer patients receiving immunotherapy

Total patients

HPD (n = 26)

SD/PR/CR (n = 129)

P value

Age (year)

58.96 ± 10.2

65.19 ± 9.1

0.002

Gender, Female: Male

3:23

35:94

0.092

Smoking history (pack/y)

29.3 ± 19.6

24.41 ± 21.6

0.284

  < 20

5

51

0.049

  ≥ 20

21

78

 

Histologic subtype

  

0.061

 Adenocarcinoma

14

93

 

 Squamous cell carcinoma

11

34

 

 Others

1

2

 

Oncogenic driver mutations

   

 Yes: No

8:18

16:113

0.018

 EGFR mutation

5

7

 

 ALK, ROS1, and others

3

9

 

Number of metastatic sites

  

0.005

  < 3

17

113

 

  ≥ 3

9

16

 

Prior treatment lines before ICBs

  

0.139

  < 3

21

117

 

  ≥ 3

5

12

 
  1. Values are presented as mean ± standard deviation, ratio, or number
  2. aNon-evaluable group and non-HPD PD group were excluded
  3. ALK Anaplastic lymphoma kinase, EGFR epidermal growth factor receptor, HPD hyperprogressive disease, Non-HPD PD non-HPD progressive disease, OS overall survival, PR/CR partial/complete response, SD stable disease