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Fig. 3 | BMC Cancer

Fig. 3

From: The implications of clinical risk factors, CAR index, and compositional changes of immune cells on hyperprogressive disease in non-small cell lung cancer patients receiving immunotherapy

Fig. 3

Immune cell composition in the tumor and stroma using Multiplex IHC. a The numbers of CD4+ and CD8+ lymphocytes are significantly smaller in the HPD group compared to those of the disease-controlled group. FOXP3 + CD4+ Treg cells are significantly larger in number in the HPD group. b CD68+ and CD163+ macrophages are more frequently observed in stroma of the HPD group, suggestive of M2 polarization. c CD11c + CAFs tend to increase and CD56+ NK cells are significantly reduced in the intra-tumoral area in the HPD group. IHC immunohistochemistry, HPD hyperprogressive disease, NK natural killer cells, DC dendritic cells. Statistical power: ** implies p value < 0.05, * implies p value < 0.5, implies p value ≥0.5 but shows a clinical correlation

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