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Fig. 7 | BMC Cancer

Fig. 7

From: EHHADH contributes to cisplatin resistance through regulation by tumor-suppressive microRNAs in bladder cancer

Fig. 7

Transfection of si-EHHADH increased sensitivity to CDDP in CDDP-R-BC cell lines. The IC50 concentration of cisplatin was given to parental BC cells. Transfection of 10 nM si-EHHADH increased the cisplatin sensitivity in (a) CDDP-R-BOY and (b) CDDP-R-T24 cells as determined by XTT assay. *, P < 0.001. The combination of si-EHHADH transfection and cisplatin administration to (c) CDDP-R-BOY and (d) CDDP-R-T24 cells clearly had an additive effect and significantly suppressed cell proliferation. *, P < 0.001. e, f Apoptosis assays were carried out using flow cytometric analysis of CDDP-R-BC cells. *, P < 0.001

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BMC Cancer

ISSN: 1471-2407

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