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Fig. 3 | BMC Cancer

Fig. 3

From: EHHADH contributes to cisplatin resistance through regulation by tumor-suppressive microRNAs in bladder cancer

Fig. 3

Effects of miRNA-486-5p restoration on cell proliferation, migration, invasion and apoptosis in CDDP-R-BC cell lines. a Expression levels of miRNA-486-5p determined by qRT-PCR were significantly lower in cisplatin-resistant BC cell lines than in parental BC cell lines. *, P < 0.05. b Cell proliferation determined by XTT assay. *, P < 0.01; * *, P < 0.001. c Cell migration activity determined with wound healing assay. *, P < 0.01; * *, P < 0.001. d Cell invasion activity determined with Matrigel invasion assay. *, P < 0.001. e Western blot analysis of apoptotic markers (cleaved PARP and PARP) in CDDP-R-BOY and CDDP-R-T24. The full-length blots/gels are presented in Supplementary Figure 8.

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BMC Cancer

ISSN: 1471-2407

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