Fig. 1

Establishment of cisplatin-resistant BC cells. a BC cells (BOY and T24) were cultured with serial concentrations of cisplatin from 0.01 to 2.0 μg/mL for 6 months. Time course comparing tumor volumes of (b) parental BOY/CDDP-R-BOY and (c) parental T24/CDDP-R-T24 after subcutaneous injection of cisplatin (4 mg/kg/mouse/week, n = 5 mice per group) *, P < 0.05. Scale bar: 10 mm. Calculated IC50 of (d) parental BOY/CDDP-R-BOY and (e) parental T24/CDDP-R-T24