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Table 1 Toxicology Assessment of R-ketorolac. Hematology results are shown from mice bearing SKOV3ip-RLuc-GFP tumors and treated with placebo or R-ketorolac at 5 mg/kg/d as described in Methods. Control mice were non-tumor bearing and did not receive drug or placebo treatments and are diet, age, and living conditions matched to the other mice on study. Reference ranges are from a strain and age (6–8 weeks) matched Nu/Nu Mouse Biochemistry Technical Sheet from Charles River. Statistical analyses were performed using one-way ANOVA followed by Tukey’s multiple comparisons test. 1Data points missing due to reported hemolysis error; error may also result when hematocrit levels are high. 2Data averages and standard deviations calculated using Regression on Order Statistics (ROS) model to include points below limit of detection (BLD). *, # Significant difference from placebo and control groups respectively. One, two, three, and four symbols indicates p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, and p ≤ 0.0001, respectively)

From: The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo

  Placebo BLD R-Ketorolac BLD Control BLD Reference Range
  Average ± SD n= n= Average ± SD n= n= Average ± SD n= n= Average ± SD n=
Albumin (g/dL) 4.43 ± 0.25 10   4.05 ± 0.40* 10   4.06 ± 0.09 5   2.8–4.0 113
Glucose (mg/dL) 222.3 ± 54.07 10   287.7 ± 81.31 10   214.20 ± 25.95 5   149–271 114
Total Bilirubin1 (mg/dL) 0.17 ± 0.06## 3   0.26 ± 0.05 9   0.32 ± 0.04 5   0.2–0.5 107
Alanine aminotransferase (U/L) 43.4 ± 19.36 10   32.30 ± 11.35 10   23.80 ± 4.55 5   31–115 105
Alkaline phosphatase1,2 (U/L) 16.58 ± 13.09#### 9 3 28.97 ± 18.75### 10 2 68.6 ± 2.51 5   76–301 114
Amylase (U/L) 1027 ± 337 10   1069 ± 264 10   858 ± 90.13 5    
Blood Urea Nitrogen (mg/dL) 18.5 ± 2.92 10   16.4 ± 2.59 10   19.0 ± 3.61 5   11–39 114
Calcium (mg/dL) 11.53 ± 0.56 10   11.58 ± 0.79 10   10.76 ± 0.42 5   9.5–12.1 114
Creatinin1,2 (mg/dL) 0.16 ± 0.08 7 4 0.24 ± 0.13 9 3 0.20 ± 0.13 5 3 0.2–0.4 107
Globulin (g/dL) 1.5 ± 0.4 9   1.77 ± 0.43 10   1.36 ± 0.18 5    
Phosphorus (mg/dL) 9.59 ± 0.78 10   9.86 ± 1.90 10   6.65 ± 0.55 5   8.0–15.5 114
Sodium (mmol/L) 149 ± 2.98 10   151.3 ± 4.11# 10   145.0 ± 4.53 5   140.7–165.1 76
Total Protein (g/dL) 5.88 ± 0.36 10   5.79 ± 0.34 10   5.44 ± 0.13 5   4.8–6.6 114
Mouse Weight (g) 24.46 ± 1.42 10   23.67 ± 1.30 10   24.28 ± 2.13 5